Results 251 to 260 of about 509,115 (295)
Some of the next articles are maybe not open access.
Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
Biometrics, 1986Suppose that a clinical trial has been carried out using a sequential design. Any analysis that neglects the monitoring of the trial is potentially biased, and this holds for analyses of responses not directly used to determine whether the study should be stopped.
openaire +2 more sources
Sequential Trials, Sequential Analysis and the Likelihood Principle
The American Statistician, 1966(1966). Sequential Trials, Sequential Analysis and the Likelihood Principle. The American Statistician: Vol. 20, No. 2, pp. 18-23.
openaire +1 more source
Bayesian sequential analysis for multiple-arm clinical trials
Statistics and Computing, 2008Use of full Bayesian decision-theoretic approaches to obtain optimal stopping rules for clinical trial designs typically requires the use of Backward Induction. However, the implementation of Backward Induction, apart from simple trial designs, is generally impossible due to analytical and computational difficulties.
Luke Akong'o Orawo, J. Andrés Christen
openaire +1 more source
Analysis of Sequential Clinical Trials
2012We discuss issues and methods for the analysis of clinical trials that have formal rules for what is commonly referred to as early stopping. However, we take a broader view, and include trials having a formal sequential stopping rule; the distinction will soon become apparent.
openaire +1 more source
A Fortran program for the design and analysis of sequential clinical trials
Computers and Biomedical Research, 1985Clinical scientists are becoming increasingly aware of the need to monitor clinical trials in progress, and to validate their procedure by the use of a formal sequential design. An interactive program, written in FORTRAN 77 and called "PEST: Planning and Evaluation of Sequential Tests," is introduced.
J, Whitehead, P, Marek
openaire +2 more sources
Incorporation of sequential trials into a fixed effects meta‐analysis
Statistics in Medicine, 1997The technique of meta-analysis provides a systematic and quantitative approach to the summary of results from a collection of similar randomized studies. Comprehensive methodology exists for analysis when all trials are of a fixed sample size design, but this is based on assumptions which are no longer valid when incorporating sequentially designed ...
openaire +2 more sources
Sequential Meta-analysis of Past Clinical Trials to Determine the Use of a New Trial
Epidemiology, 2006Clinical trials can be stopped early based on interim analyses or sequential analyses. In principle, sequential analyses can also be used to decide whether enough evidence has been gathered in completed trials to make further trials unnecessary. We demonstrate such an application through a retrospective analysis of clinical trials comparing ventilation
Bollen, C.W. +3 more
openaire +3 more sources
How to perform and write a trial sequential analysis
Anaesthesia, 2022P. R. D. Clephas, P. Kranke, M. Heesen
openaire +3 more sources
Sequential Analysis with Applications to Clinical Trials
2012The topic of the thesis is an overview of some sequential and change-point detection methods with applications to clinical trials. Performing sequential monitoring is important for ethical, economical and other reasons. It is important to terminate a study as soon as possible when potentially harmful treatments are used or when financial resources are ...
openaire +1 more source
Heart
Background Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) among young individuals and athletes. Despite increasing evidence supporting exercise, uncertainty remains about its safety and efficacy in this population ...
Vinicius Machado Correia +9 more
openaire +2 more sources
Background Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) among young individuals and athletes. Despite increasing evidence supporting exercise, uncertainty remains about its safety and efficacy in this population ...
Vinicius Machado Correia +9 more
openaire +2 more sources