Results 141 to 150 of about 167,987 (303)

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter studyCentral MessagePerspective

JTCVS Open
Objective: The study objective was to determine if intraoperative peritoneal catheter placement is associated with improved outcomes in neonates undergoing high-risk cardiac surgery with cardiopulmonary bypass.
David M. Kwiatkowski, MD, MS, Jeffrey A. Alten, MD, Kenneth E. Mah, MD, David T. Selewski, MD, Tia T. Raymond, MD, MBA, Natasha S. Afonso, MD, MPH, Joshua J. Blinder, MD, Matthew T. Coghill, MD, David S. Cooper, MD, MPH, Joshua D. Koch, MD, Catherine D. Krawczeski, MD, David L.S. Morales, MD, Tara M. Neumayr, MD, A.K.M. Fazlur Rahman, PhD, Garrett Reichle, MS, Sarah Tabbutt, MD, PhD, Tennille N. Webb, MD, Santiago Borasino, MD, Huaiyu Zang, David Winlaw, MD, David Bailly, DO, Stuart Goldstein, MD, Katja Gist, DO, Katie L. Brandewie, MD, Priya N. Bhat, MD, John W. Diddle, MD, Muhammad Ghbeis, MD, Parthak Prodhan, MD, Xiomara Garcia, MD, Shannon Ramer, Mindy Albertson, Zahidee Rodriquez, MD, Mary Lukacs, Michael Gaies, MD, Joshua Freytag, Amanda Sammons, Hideat Abraha, John Butcher, Dominic Zanaboni, MD, Joan Sanchez de Toledo, MD, PhD, Yuliya A. Domnina, MD, Lucas Saenz, MD, Tracy Baust, Jane Kluck, RN, Jun Sasaki, MD, Aanish Raees, MD, Erika R. O'Neil, MD, Javier J. Lasa, MD, Patrick A. Phillips, Kristal M. Hock, Kevin Valentine, MD, Sachin Tadphale, MBBS, Jason R. Buckley, MD, Luke Schroeder, MD, Shanelle Clarke, MD, Wenying Zhang, MD, Andrew Smith, MD, Mohammed Absi, MD, David J. Askenazi, MD, Patrick A. Phillips, Kristal M. Hock, David J. Askenazi, Parthak Prodhan, Xiomara Garcia, Shannon Ramer, Mindy Albertson, Shanelle Clarke, Zahidee Rodriquez, Muhammad Ghbeis, Jun Sasaki, Katie L. Brandewie, Mary Lukacs, Katja Gist, Michael Gaies, Joshua Freytag, Amanda Sammons, Hideat Abraha, John Butcher, Aanish Raees, Dominic Zanaboni, Joan Sanchez de Toledo, Yuliya A. Domnina, Tracy Baust, Lucas Saenz, John W. Diddle, Jane Kluck, Linda Duncan, Rebecca A. Bertrandt, Lisa J. Sosa, Priya N. Bhat, Erika R. O’Neal, Javier J. Lasa, Kevin Valentine, Jason R. Buckley, Luke Schroeder, Tammy Doman, Suzanne Viers, Wenying Zhang, Andrew H. Smith, Sachin Tadphale, Mohammed Absi, David K. Bailly   +101 more
doaj   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

The value of multimodality imaging for detection, characterisation and management of a wall adhering structure in the right atrium [PDF]

, 2014
The case presents a wall adherent structure in the right atrium in a young patient with peripheral tcell lymphoma followed by successful prolonged lysis therapy resulting in the resolution of the thrombus is presented.
Akin, Ibrahim, Baumann, Stefan, Becher, Tobias, Behnes, Michael, Boecker, C., Borggrefe, Martin, Frambach, Daniel, Huseynov, Aydin, Papavassiliu, Theano, Rapp, S.   +9 more
core   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Flexible IMU Sensor Array For 3D Colonoscope Shape Reconstruction and AI‐Based Loop Detection

Advanced Science, EarlyView.
We propose a sensing platform for 3D visualization of the colonoscope combined with artificial intelligence (AI)‐based loop detection. The system consists of an array of 15 inertial measurement units (IMUs) mounted on a flexible printed circuit board that can be retrofitted into the instrument channel of conventional colonoscopes.
Tuukka Panula, Anni Halkilahti, Andrei Ivanov, Matti Kaisti   +3 more
wiley   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Integrated Hydrophilic Interdigitated Network for Silicone Rubber via a Gradient Polarity Modification Strategy

Advanced Science, EarlyView.
This work overcomes the long‐standing challenge of hydrophilic modification of silicone rubber via a gradient polarity modification strategy. By constructing a hydrophilic interpenetrating network within cured SR, simultaneous surface‐to‐bulk modification is achieved while enabling monitoring through a Eu3+ complex fluorescent tracer.
Lihui Zhang, Rui Wang, Pingru Su, Yao Kou, Zhengfeng Ma, Hui Tang, Mingying Wang, Lixin Wang, Chunyu Zhou, Shuanhong Ma, Yu Tang, Feng Zhou   +11 more
wiley   +1 more source