Results 221 to 230 of about 66,004 (283)

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Patient and Physician Perspectives on Pharmacotherapy in Parkinson's Disease Psychosis: A Mixed-Methods Exploratory Study. [PDF]

Pharmacy (Basel)
Rose O, Hinteregger T, Trinka E, Iglseder B, Pachmayr J, Clemens S.   +5 more
europepmc   +1 more source

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

Advanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng, Shaokun Wang, Jiehan Zou, Guiwen Shi, Zhongxue Gan, I‐Ming Chen, Guo‐Niu Zhu   +6 more
wiley   +1 more source

Utilizing the Practical Robust, Implementation and Sustainability Model to Explore the Primary Care Setting Contextual Determinants of Implementing Patient-Reported Outcomes Measures to Support Opioid Use Disorder Care. [PDF]

Implement Res Pract
Pytell JD, Macht A, Rinehart DJ, Gilbert A, Lockhart S, King L, Fraumeni B, Duarte KG, Binswanger IA, Albright K, Huebschmann AG.   +10 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Challenges and opportunities for expediting ALS diagnosis in Alberta, Canada: a human-centred design approach. [PDF]

BMJ Open
Ofosu NN, Luth W, Genuis SK, Tymkow K, Budiyanto I, McGuckin T, Campbell-Scherer D, Johnston WS.   +7 more
europepmc   +1 more source

Customizing Tactile Sensors via Machine Learning‐Driven Inverse Design

Advanced Science, EarlyView.
ABSTRACT Replicating the sophisticated sense of touch in artificial systems requires tactile sensors with precisely tailored properties. However, manually navigating the complex microstructure‐property relationship results in inefficient and suboptimal designs.
Baocheng Wang, Depeng Kong, Zhiao He, Jikai Liang, Yuyao Lu, Zikang Deng, Honghe Li, Mengke Wang, M. Jamal Deen, Zhiqiu Ye, Shuyao Zhou, Huayong Yang, Honghao Lyu, Jun Chen, Kaichen Xu, Geng Yang   +15 more
wiley   +1 more source

Risky Drinking in Midlife Men: Insights From Australia's National Drug Strategy Household Survey. [PDF]

Drug Alcohol Rev
Zaccagnini S, Bartram A, Livingston M, Smith JA, Bovopoulos N, Bowden J.   +5 more
europepmc   +1 more source