Results 121 to 130 of about 6,463 (217)

Water pollution drives environmental degradation in a seasonally influenced Neotropical coastal river. [PDF]

Environ Monit Assess
da S Belanha L, Paz OLS, Padial AA, de Azevedo JCR, Hughes RM, Ruaro R.   +5 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Neglected Microplastics and Their Risks in Rivers Throughout the Three Gorges Reservoir Area. [PDF]

Toxics
Xie JY, Li B, Jia QP, Li X, Zhao Q, Fan PD, Wang CQ, Zhang LY.   +7 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Notes on ecological state of Izh reservoir and its tributaries in autumn period of 2023

SOCIALNO-ECOLOGICHESKIE TECHNOLOGII
openaire   +1 more source

Assessment of Chromium Contamination in Aquatic Environments near Tannery Industries: A Portuguese Case Study. [PDF]

Toxics
Silva LJG, Casimiro MJG, Pena A, Campos MJ, Pereira AMPT.   +4 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Venous flow phasicity is not caused by the thoracoabdominal pump, but results from luminal deformation of the inferior vena cava caused by respiratory diaphragmatic movement. [PDF]

J Vasc Surg Venous Lymphat Disord
Raju S, Kendrick S, Stone RH, Saleem T.
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Acid mine drainage control in mining areas: identification of groundwater recharge pathways and source reduction strategies. [PDF]

Sci Rep
Zhang C, Zhang F, Mu W, Li H.
europepmc   +1 more source