Results 161 to 170 of about 5,748 (208)

Biosynthesis of Trichothecenes and Apotrichothecenes

Journal of Agricultural and Food Chemistry, 1999
Fusarium culmorum produces two major trichothecenes, 3-acetyldeoxynivalenol and sambucinol, and some minor apotrichothecenes. It was desired to investigate if during their biosynthesis a C-11-keto intermediate was involved. To verify this postulate, trichodiene, a known precursor to trichothecenes, was synthesized with two deuteriums at C-11 and one at
L O, Zamir, A, Nikolakakis, F, Sauriol, O, Mamer   +3 more
openaire   +2 more sources

Haematotoxicity of trichothecenes

Toxicology Letters, 2004
Human toxicosis induced by consumption of foodstuffs contaminated with trichothecenes presents one common major symptom: a haematological perturbation manifesting principally as thrombocytopenia and leukopenia. The patients have rapidly progressing coagulation problems, and compromised resistance to infections.
openaire   +2 more sources

Prevention strategies for trichothecenes

Toxicology Letters, 2004
Contamination of cereal commodities with mycotoxins represents a significant hazard to consumer health and has thus received increasing attention from food safety authorities and legislators. For trichothecenes, and deoxynivalenol (DON) in particular, the imminent implementation of legislative limits has focused attention on ways to prevent entry of ...
David, Aldred, Naresh, Magan
openaire   +2 more sources

ROS: Trichothecenes’ handy weapon?

Food and Chemical Toxicology, 2020
Trichothecenes are a class of toxic secondary metabolites produced by filamentous fungi such as Fusarium, which pose a threat to human and animal health. Among them, T-2 toxin and deoxynivalenol (DON) have attracted the most attention because of their extensive pollution and strong toxicity.
Zhihua Ren, Hongyi He, Zhicai Zuo
exaly   +3 more sources

Mode of action of trichothecenes

Pure and Applied Chemistry, 1977
Abstract
openaire   +2 more sources

Chemical Synthesis of the Trichothecenes

1985
That research in the trichothecene field is an area of intense interest cannot be disputed. In the years 1982 and 1983, there were more than 500 publications dealing with this subject, including more than 30 reviews. In addition, a comprehensive monograph has recently appeared (151).
P G, McDougal, N R, Schmuff
openaire   +2 more sources

A yeast bioassay for trichothecenes

Natural Toxins, 1999
Like all eucaryotic cells, yeasts are sensitive to trichothecenes, especially T-2 toxin and verrucarin A. Based on this sensitivity, a yeast bioassay was developed to evaluate the toxicity of corn samples. The bioassay was optimized using spiked maize extracts. The toxicity of samples was defined as toxicity equivalent to a certain concentration of T-2
openaire   +2 more sources

Targeting Trichothecene Biosynthetic Genes

2016
Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong, van der Lee, Theo, Verstappen, Els, van Gent, Marga, Waalwijk, Cees   +4 more
openaire   +2 more sources

Trichothecenes and their analysis

Journal of the American Oil Chemists' Society, 1979
AbstractThe analysis of foods and feeds for the naturally occurringFusarium produced trichothecenes is reviewed. Each major step (extraction, purification and detection‐quantitation) is discussed. Although none of the extraction solvents has been thoroughly evaluated, aqueous metanol is the preferred system in most of the published procedures.
openaire   +1 more source

HPLC-MS-Method for A-Trichothecenes

Mycotoxin Research, 2001
Gaschromatography with electron capture detection belongs to the most important methods for analysing the A-trichothecenes T-2 toxin, HT-2 toxin and diacetoxyscirpenol. The need of a derivatisation for these mycotoxins prior detection is the main disadvantage of this method.
N, Thimm, J, Handl, M, Binder
openaire   +2 more sources