Results 31 to 40 of about 135,860 (206)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Physiological and clinical consequences of relief of right ventricular outflow tract obstruction late after repair of congenital heart defects. [PDF]

, 2006
BACKGROUND: Right ventricular outflow tract obstruction (RVOTO) is a common problem after repair of congenital heart disease. Percutaneous pulmonary valve implantation (PPVI) can treat this condition without consequent pulmonary regurgitation or ...
Sridharan, S, Schievano, S, Coats, L, Jones, R, Mist, B, Taylor, AM, Deanfield, JE, Bonhoeffer, P, Derrick, G, Khambadkone, S, Pellerin, D   +10 more
core  

What went wrong? The flawed concept of cerebrospinal venous insufficiency [PDF]

, 2013
In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis (MS), coining the term of chronic cerebrospinal venous insufficiency ('CCSVI'). The diagnosis of 'CCSVI' is
Schreiber, SJ, Doepp, F, Schreiber, S.J., Paul, F., van Oosten, BW, Wattjes, MP, Paul, F, Valdueza, JM, Doepp, F., Wattjes, M.P., Schmierer, K, Valdueza, J.M., Schmierer, K., van Oosten, B.W.   +13 more
core   +1 more source

Surgical Treatment of Unusual Anatomy of the Tricuspid Valve in Ebstein’s Anomaly

Український журнал серцево-судинної хірургії
Ebstein’s anomaly is a congenital heart disease in which the septal and posterior leaflets of the tricuspid valve are displaced to the apex of the right ventricle, forming its atrialization.
Hanna V. Maistriuk, Iaroslav P. Truba, Serhii M. Boyko, Ivan V. Dziuryi   +3 more
doaj   +1 more source

Actual Experience of One and a Half Ventricle Repair in Patients with Ebstein’s Anomaly

Український журнал серцево-судинної хірургії, 2019
Introduction. Ebstein’s anomaly (EA) is a complex congenital heart defect involving mainly tricuspid valve (TV), right atrium and right ventricle (RV).
V. А. Khanenova, O. V. Stogova, A. Y. Hrytsaiuk, Y. L. Kuzmenko, M. S. Meshkova, T. A. Yalynska, R. M. Kostrakevych, І. М. Yemets   +7 more
doaj   +1 more source

Reversible third-degree atrioventricular block in a Poodle-Toy with degenerative mitral valve disease and pyometra

Brazilian Journal of Veterinary Medicine, 2021
Third degree atrioventricular block is a severe arrhythmia, being the most common   indication for artificial cardiac pacing in dogs. Spontaneous reversion to normal sinus rhythm is very rare or exceptional.
Gustavo Luiz Gouvêa Almeida, Marcelo Barbosa de Almeida, Ana Carolina Mendes dos Santos, Ângela Vargas, Valéria Duarte Reis   +4 more
doaj   +1 more source

Systematic Cardiac Phenotyping of Patients With Copy Number Variants in the 15q11.2 Breakpoint 1 to Breakpoint 2 Region: A Retrospective Cohort Study From Nine Pediatric Cardiac Centers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright, Maria B. Padua, Lindsey R. Helvaty, Kim L. McBride, Gabrielle Geddes, Vidu Garg, Seema R. Lalani, Stephanie Burns Wechsler, Jennelle C. Hodge, Benjamin J. Landis, Stephanie M. Ware   +10 more
wiley   +1 more source

Initial clinical experience with a novel biodegradable ring in patients with functional tricuspid insufficiency: Kalangos Biodegradable Tricuspid Ring

, 2007
Tricuspid annuloplasty procedures have been widely performed in clinics for many years. The Kalangos Biodegradable Tricuspid Ring (Kalangos Biodegradable Tricuspid Ring, Bioring SA, Lonay, Switzerland) is a novel prosthesis for the treatment of tricuspid
Pektok, Erman, Ustunsoy, H, Celkan, M A, Burma, O, Kazaz, H, Davutoglu, V   +5 more
core   +1 more source

Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome [PDF]

, 1991
The echocardiographic studies and clinical course of 27 fetuses (mean gestationl age 26.9 weeks) diagnosed in utero with tricuspid valve disease and significant tricuspid regurgitation were reviewed.
Sahn, David J., Hornberger, Lisa K., Reed, Kathryn L., Kleinman, Charles S., Copel, Joshua A.   +4 more
core   +1 more source

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source