Results 141 to 150 of about 145,419 (376)

Synthesis of Siphonazole B Through Domino Cycloisomerization‐Oxazolonium Ion Rearrangements

Chemistry – A European Journal, EarlyView.
The study by Strand and co‐workers describes a concise synthesis of siphonazole B. Both oxazole units are formed from a simple propargylamine using a novel domino cycloisomerization‐rearrangement approach. Additional synthetic features include a direct aldol‐type reaction for assembling the tricyclic siphonazole core and an oxidative amidation reaction
Filip Paulsen, Sebastian Clementson, Henrik von Wachenfeldt, Michał Antoszczak, Simon Fridolf, Daniel Strand   +5 more
wiley   +1 more source

A Rapid and Simple Method for the Quantification in Human Plasma of Tricyclic Antidepressant Drugs Taken in Overdose [PDF]

, 1979
W. D. Mitchell, Sarah F. Webb, George R. A. Padmore   +2 more
openalex   +1 more source

Functionalized in Triplicate: A Ring‐By‐Ring Approach to Tailored Prodiginine Derivatives for Site‐Specific Conjugation Through Click Chemistry

Chemistry – A European Journal, EarlyView.
Prodigiosin is a potent cytotoxic alkaloid but lacks target selectivity. We advance functionalization of all three pyrrole rings of prodigiosin to enable site‐specific conjugation via click chemistry. The presented azide‐ and maleimide‐functionalized prodiginines are suitable for generating covalent prodiginine conjugates and attaching auspicious ...
T. Moritz Weber, Jörg Pietruszka
wiley   +1 more source

Acid-catalyzed Hydrolyses of Bridged Bi- and Tricyclic Compounds. VIII. Kinetics of 2-Methyl-exo-2-norbornenyl Acetate and Its Intermediate Products in Dioxane--Water Mixtures. [PDF]

, 1976
Martti Lajunen, Heikki Lyytikäinen, Inge Skauvik, Arne F. Andresen, M. Sandström   +4 more
openalex   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Antidepressants versus placebo for depression in primary care [PDF]

, 2009
Arroll, Bruce, Blashki, Grant, Elley, C. Raina, Fishman, Tana, Goodyear-Smith, Felicity A., Kenealy, Tim, Kerse, Ngaire, MacGillivray, Stephen   +7 more
core   +2 more sources

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

ChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı   +2 more
wiley   +1 more source

What are tricyclic antidepressant drugs [letter]? [PDF]

, 1975
A. C. Tait, A Todrick
openalex   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Hypertensive Episodes After Adding Methyiphenidate (Ritalin) to Tricyclic Antidepressants (Report of Three Cases and Review of Clinical Advantages)

, 1972
Abraham Flemenbaum
openalex   +1 more source