Results 151 to 160 of about 109,999 (323)

Prevalence and Clinical Correlates of Sleep Disorders in RFC1‐Spectrum Disorders: A Cross‐Sectional Study

Movement Disorders, EarlyView.
The RFC1‐spectrum disorders include multisystem manifestations that extend beyond cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS). Sleep disorders constitute a significant component of the disease's non‐motor spectrum. Obstructive sleep apnea, restless legs syndrome, periodic limb movements of sleep, and insomnia are common in
Antonio Funcis, Valerio Brunetti, Salvatore Rossi, Giammarco Dalla Zanna, Martina de Scisciolo, Giulia Maneri, Enrico Di Stasio, Antonio Petrucci, Giacomo Della Marca, Gabriella Silvestri   +9 more
wiley   +1 more source

Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Visual hallucinations (VHs) are a common feature of Parkinson's disease (PD) believed to arise from disruptions to the functional architecture supporting sensory integration and attentional control. Across synucleinopathies, increased pathological burden in the amygdala and deficits in cholinergic modulation have been linked to VHs.
Anna Ignatavicius, Lachlan Churchill, Jack Anderson, Ajay Konuri, Claire O'Callaghan, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Highly efficient construction of angular polycycles

Nature Communications
Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. We herein report the Lewis acids-catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring, by which ...
Yi Sun, Xiaobing Huang, Jun Ren, Zhongwen Wang   +3 more
doaj   +1 more source

Liquid Chromatographic Method for Identity, Assay, and Content Uniformity of Five Tricyclic Drugs [PDF]

, 1985
Edward G Lovering, Normand Beaulieu, R. C. Lawrence, R.W. Sears   +3 more
openalex   +1 more source

Tricyclic Click

Psychosomatics, 1990
M S, Komrad, J P, Federoff
openaire   +2 more sources

Continuous‐Wave (CW) Photo‐CIDNP NMR Spectroscopy: A Tutorial

Magnetic Resonance in Chemistry, EarlyView.
ABSTRACT Photo‐chemically induced dynamic nuclear polarisation (photo‐CIDNP) is a nuclear spin‐selective magnetic resonance phenomenon that has traditionally been used to mechanistically study chemical reactions involving the (transient) formation of radical molecular species, extract EPR observables of short‐lived radicals, probe biomolecular ...
Lars T. Kuhn, Míriam Pérez‐Trujillo
wiley   +1 more source

Pharmacological studies on 2-(4-Methylaminobutoxy)diphenylmethane hydrochloride (MCI-2016), a new non-tricyclic compound (I) Anti-depressant action

, 1979
Akihiro Tobe, Yoshimasa Yoshida, Hidenobu Ikoma, Shinji Tonomura, Ryoji Kikumoto   +4 more
openalex   +1 more source

Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐MAINTAIN aims to evaluate the efficacy and safety of reducing the tirzepatide dose and/or continuing the maximum tolerated dose (MTD) versus placebo in maintaining body weight (BW) reduction achieved with tirzepatide MTD. Methods This Phase 3b, multicenter, randomized, parallel‐arm, double‐blinded, placebo‐controlled, 52 ...
Deborah B. Horn, Louis J. Aronne, Sean Wharton, Harold E. Bays, Elisa Gomez‐Valderas, Avigdor D. Arad, Palash Sharma, Julia P. Dunn, Cagri Senyucel, Clare J. Lee   +9 more
wiley   +1 more source

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, EarlyView.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source