Results 161 to 170 of about 140,376 (301)

Action of Betulinic Acid in the Inhibition of Efflux Pump NorA in Staphylococcus aureus Strains: In Vitro and In Silico Approaches

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT Antibiotic resistance poses a serious challenge to public health, particularly in the case of Staphylococcus aureus, a Gram‐positive bacterium that employs multiple resistance mechanisms, including efflux pumps such as NorA, which extrude antimicrobial compounds from the cell and reduce antibiotic efficacy. Therefore, the search for substances
Camila Aparecida Pereira da Silva, Nara juliana Santos Araujo, Cícera Datiane Morais Oliveira‐Tintino, José Maria Barbosa Filho, Gabriel Gonçalves Alencar, José Bezerra de Araújo‐Neto, Josefa Sayonara dos Santos, Juliete Bezerra Soares, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade‐Pinheiro   +10 more
wiley   +1 more source

From Struggling (With) Screening Tests to Mouse Models of Depression‐Relevant Neurobehavioral States

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract A major, serendipitous psychiatric discovery is monoamine‐transporter reuptake inhibition as an antidepressant mechanism of action. Chronic treatment with such antidepressants is efficacious, with onset requiring 1‐2 weeks, in many but by no means all patients with major depressive or another stress‐related neuropsychiatric disorder.
Christopher R. Pryce
wiley   +1 more source

Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease

Journal of Clinical Gastroenterology, 2014
Heba N. Iskandar, MD Benjamin Cassell, MD Navya Kanuri, MD C. Prakash Gyawali, MD Mph Alexandra Gutierrez, MD Themistocles Dassopoulos, MD Matthew A. Ciorba, M. M. Gregory S. Sayuk   +7 more
semanticscholar   +1 more source

Development and Validation of the Brief Inventory of Treatment Expectations in Chronic Pain (BITEC)

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Expectations shape therapeutic outcomes, yet their systematic assessment remains limited in clinical and research settings. To address this gap, we developed and validated the Brief Instrument for the Assessment of Treatment Expectations in Chronic Pain (BITEC) using Item Response Theory. Methods The study comprised four phases. (I)
Wolnei Caumo, Bárbara Regina França, Jaira Ehlers, Stela Maris de Jezus Castro, Rogério Boff Borges, Vania Naomi Hirakata, Graziele Borges Bueno, Iraci LS da Torres, Felipe Fregni   +8 more
wiley   +1 more source

Chiral hypervalent iodine catalyzed stereoselective skeletal editing of pyrimidine fused heterocycles. [PDF]

Nat Commun
Sun WW, Xie YB, Wu B.
europepmc   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari, Setare Abolghasemi, Elham Khanniri, Maryam Bayanati, Rahil Hakimimofrad, Mohammad Mahboubi‐Rabbani   +5 more
wiley   +1 more source

Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Advances in the Total Synthesis of Angular Triquinane-Type Natural Products. [PDF]

Molecules
Wang X, Liu D, Cheng Y.
europepmc   +1 more source

Duplicate Prescription Patterns in Patients With Substance Use Disorders

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT This study sought to investigate the frequency and characteristics of duplicate prescriptions (DPs) in psychiatric inpatients with substance use disorders using a DP classification that differentiates between appropriate DPs (ADPs) and potentially inappropriate DPs (PIDPs). The study was conducted as a monocentric retrospective cross‐sectional
Johannes Heck, Benjamin Krichevsky, Martin Schulze Westhoff, Konstantin Fritz Jendretzky, Martin Klietz, Stephan Greten, Alexander Glahn, Stefan Bleich, Sebastian Schröder   +8 more
wiley   +1 more source