Results 11 to 20 of about 98,241 (368)

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Marine Drugs, 2015
Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently ...
Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis   +5 more
doaj   +1 more source

Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives [PDF]

, 2016
Tricyclic isotaxane and taxane derivatives and have been synthesized by a very efficient cascade ring-closing dienyne metathesis (RCDEYM) reaction, which formed the A and B rings in one operation.
Aouzal, Remi, Farrugia, Louis J., Letort, Aurelien, Ma, Cong, Maiti, Gourhari, Prunet, Joelle, Ricard, Louis, Wilkes, Antonia   +7 more
core   +3 more sources

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]

, 2014
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J., Aldegunde M. J., Aldegunde M. J., Aurélien Letort, Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Chatterjee A. K., Cong Ma, De-Liang Long, Doi T., Garber S. B., Goldring P. D., Grieco P. A., Holton R. A., Holton R. A., Joëlle Prunet, Kim S.-H., Ma C., Masters J. J., Mendoza A., Morihara K., Mukaiyama T., Muller B., Muller B., Nicolaou K. C., Rémi Aouzal, Schiltz S., Scholl M., Schwab P., Swindell C. S., Wender P. A., Wender P. A., Wilde N. C., Winkler J. D., Yamazaki Y., Yared J. A., Yvon D.   +39 more
core   +3 more sources

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia. [PDF]

, 2020
ObjectivesEarly recognition of dementia would allow patients and their families to receive care earlier in the disease process, potentially improving care management and patient outcomes, yet nearly half of patients with dementia are undiagnosed. Our aim
Barnes, Deborah E, Boscardin, W John, Dublin, Sascha, Larson, Eric B, Lee, Sei J, Marcum, Zachary A, Walker, Rod L, Zhou, Jing   +7 more
core   +2 more sources

Biomarker Indicators of Source and Depositional Environment for the Organic Matters within Barsarin Formation (Upper Jurassic) in Kirkuk and Taq Taq Oil Fields, Northern Iraq [PDF]

Kirkuk Journal of Science, 2008
The GC, GC/MS analysis for twelve bitumen extracts from Barsarin Formation in the wells K-109 and Tq-1 (Kirkuk and Taq Taq oil fields respectively) and for two oil samples from K-156 and Tq-1 wells revealed a euxinic, carbonate marine to mix environment ...
Dler H. Baban and Shadan M. Ahmed
doaj   +1 more source

Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats [PDF]

, 2010
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells.
Asanuma, Masato, Doi, Maho, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Matsunaga, Hisashi, Miyazaki, Ikuko, Nagamachi, Tomoko, Sendo, Toshiaki, Shinomiya, Kazuaki   +9 more
core   +1 more source

Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function.

Frontiers in Pharmacology, 2013
Depression is a major health problem for which most patients are not effectively treated. This problem is further compounded in children and adolescents where only two antidepressants [both selective serotonin reuptake inhibitors (SSRIs)] are currently
Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter eKoek, Lynette C Daws   +4 more
doaj   +1 more source

Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age.

PLoS ONE, 2020
IntroductionThe relationship between benzodiazepines, opioids and tricyclic antidepressants and trauma is of great importance because of increased consumption and the growing evidence of a positive association among older adults.
Sergio Cordovilla-Guardia, Tania Bautista Molina, Cristina Franco-Antonio, Esperanza Santano-Mogena, Raquel Vilar-López   +4 more
doaj   +1 more source

Claims Data Analysis on the Dispensing of Tricyclic Antidepressants Among Patients With Dementia in Germany

Frontiers in Pharmacology, 2019
Objective: A restrictive use of tricyclic antidepressants (TCA) in patients with dementia (PwD) is recommended due to the hazard of anticholinergic side effects.
Philipp Hessmann, Philipp Hessmann, Jan Zeidler, Jona Stahmeyer, Sveja Eberhard, Jonathan Vogelgsang, Mona Abdel-Hamid, Claus Wolff-Menzler, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Bernhard Kis   +11 more
doaj   +1 more source

The Aα-spectral radius of complements of bicyclic and tricyclic graphs with n vertices

Special Matrices, 2021
Recently, the extremal problem of the spectral radius in the class of complements of trees, unicyclic graphs, bicyclic graphs and tricyclic graphs had been studied widely.
Chen Chaohui, Peng Jiarong, Chen Tianyuan   +2 more
doaj   +1 more source