Results 11 to 20 of about 140,160 (311)

Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter

Pharmaceutics, 2020
The cellular delivery of cell-impermeable and water-insoluble molecules remains an ongoing challenge to overcome. Previously, we reported amphipathic cyclic peptides c[WR]4 and c[WR]5 consisting of alternate arginine and tryptophan residues as nuclear ...
Sumit Kumar, Dindyal Mandal, Shaima Ahmed El-Mowafi, Saghar Mozaffari, Rakesh Kumar Tiwari, Keykavous Parang   +5 more
doaj   +1 more source

Fused Tricyclic Guanidine Alkaloids: Insights into Their Structure, Synthesis and Bioactivity

Marine Drugs, 2022
A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products.
Nur Zahirah Abd Rani, Yean Kee Lee, Sarfraz Ahmad, Ramu Meesala, Iskandar Abdullah   +4 more
doaj   +1 more source

Path energy of two kinds of special tricyclic graphs

Journal of Hebei University of Science and Technology, 2020
Aiming at the problem that there are many kinds of tricyclic graphs and the complexity of path matrix is high, the path energy of two kinds of tricyclic graphs with or without pendant vertices was studied by means of matrix analysis, the existence ...
Wenjing LI, Yanling SHAO
doaj   +1 more source

Study of cascade ring-closing metathesis reactions en route to an advanced intermediate of Taxol [PDF]

, 2016
A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10 and C13. The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has
Letort, Aurélien, Long, De-Liang, Prunet, Joëlle   +2 more
core   +1 more source

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Marine Drugs, 2015
Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently ...
Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis   +5 more
doaj   +1 more source

Hitting times for random walks on tricyclic graphs

AKCE International Journal of Graphs and Combinatorics, 2023
Let G be a simple connected graph and [Formula: see text] Let [Formula: see text] be the expected hitting time from x to y in G and [Formula: see text] be the hitting time of G, where [Formula: see text] A tricyclic graph is a simple connected graph that
Xiao-Min Zhu, Xu Yang
doaj   +1 more source

Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives [PDF]

, 2016
Tricyclic isotaxane and taxane derivatives and have been synthesized by a very efficient cascade ring-closing dienyne metathesis (RCDEYM) reaction, which formed the A and B rings in one operation.
Aouzal, Remi, Farrugia, Louis J., Letort, Aurelien, Ma, Cong, Maiti, Gourhari, Prunet, Joelle, Ricard, Louis, Wilkes, Antonia   +7 more
core   +3 more sources

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]

, 2014
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J., Aldegunde M. J., Aldegunde M. J., Aurélien Letort, Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Chatterjee A. K., Cong Ma, De-Liang Long, Doi T., Garber S. B., Goldring P. D., Grieco P. A., Holton R. A., Holton R. A., Joëlle Prunet, Kim S.-H., Ma C., Masters J. J., Mendoza A., Morihara K., Mukaiyama T., Muller B., Muller B., Nicolaou K. C., Rémi Aouzal, Schiltz S., Scholl M., Schwab P., Swindell C. S., Wender P. A., Wender P. A., Wilde N. C., Winkler J. D., Yamazaki Y., Yared J. A., Yvon D.   +39 more
core   +3 more sources

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia. [PDF]

, 2020
ObjectivesEarly recognition of dementia would allow patients and their families to receive care earlier in the disease process, potentially improving care management and patient outcomes, yet nearly half of patients with dementia are undiagnosed. Our aim
Barnes, Deborah E, Boscardin, W John, Dublin, Sascha, Larson, Eric B, Lee, Sei J, Marcum, Zachary A, Walker, Rod L, Zhou, Jing   +7 more
core   +2 more sources

Beyond depression: Other uses for tricyclic antidepressants

Cleveland Clinic journal of medicine, 2019
Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label.
J. Schneider, M. Patterson, X. Jiménez
semanticscholar   +1 more source