Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]
, 2020 Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie +9 more
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Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]
, 2014 An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J. +39 more
core +3 more sources
Frontiers in Pharmacology, 2019 Objective: A restrictive use of tricyclic antidepressants (TCA) in patients with dementia (PwD) is recommended due to the hazard of anticholinergic side effects.
Philipp Hessmann +11 more
doaj +1 more source
Hitting times for random walks on tricyclic graphs
AKCE International Journal of Graphs and Combinatorics, 2023 Let G be a simple connected graph and [Formula: see text] Let [Formula: see text] be the expected hitting time from x to y in G and [Formula: see text] be the hitting time of G, where [Formula: see text] A tricyclic graph is a simple connected graph that
Xiao-Min Zhu, Xu Yang
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
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Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Study of cascade ring-closing metathesis reactions en route to an advanced intermediate of Taxol [PDF]
, 2016 A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10 and C13. The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has
Letort, Aurélien +2 more
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Sleep Dysfunction in Fibromyalgia and Therapeutic Approach Options [PDF]
, 2020 Fibromyalgia, characterised by persistent pain, sleep disturbance, fatigue and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Lawson, Kim
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IUCrData, 2020 The tricyclic core in the title compound, C26H34O4Si2, shows disorder of the furan ring and deviates slightly from planarity, with the largest displacement from the least-squares plane [0.166 (2) Å] for the major disordered part of the methine C atom. To
Matthias Weil +2 more
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Biomarker Indicators of Source and Depositional Environment for the Organic Matters within Barsarin Formation (Upper Jurassic) in Kirkuk and Taq Taq Oil Fields, Northern Iraq [PDF]
Kirkuk Journal of Science, 2008 The GC, GC/MS analysis for twelve bitumen extracts from Barsarin Formation in the wells K-109 and Tq-1 (Kirkuk and Taq Taq oil fields respectively) and for two oil samples from K-156 and Tq-1 wells revealed a euxinic, carbonate marine to mix environment ...
Dler H. Baban and Shadan M. Ahmed
doaj +1 more source