Results 11 to 20 of about 140,376 (301)

Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel

Nature Communications, 2017
Tricyclic furanic compounds with multiple chiral centers are found in a variety of natural products. Here, the authors show a highly enantioselective nickel-catalyzed procedure to access tricyclic oxygen-containing scaffolds with five contiguous chiral ...
Ravindra Kumar, Yoichi Hoshimoto, Eri Tamai, Masato Ohashi, Sensuke Ogoshi   +4 more
doaj   +2 more sources

Asymmetric total synthesis of tricyclic prostaglandin D2 metabolite methyl ester via oxidative radical cyclization [PDF]

Beilstein Journal of Organic Chemistry
Prostaglandin D2 (PGD2) is a key pathophysiological mediator in many human diseases and biological pathways. Tricyclic prostaglandin D2 metabolite methyl ester (tricyclic-PGDM methyl ester), the major urinary metabolite of PGD2, can be used as a clinical
Miao Xiao, Liuyang Pu, Qiaoli Shang, Lei Zhu, Jun Huang   +4 more
doaj   +2 more sources

Concise synthesis of chiral tricyclic γ-lactams via synergistic isothiourea/Ir catalyzed asymmetric [3 + 2] annulation [PDF]

Nature Communications
Accessing trans-fused N-fused tricyclic frameworks with multiple contiguous stereocenters remains a major challenge in synthesis. We report a synergistic isothiourea/Ir-catalyzed [3 + 2] annulation of arylacetic acid esters with azabenzonorbornadienes ...
Guorong Xiao, Mengjiao Yang, Duanyang Kong   +2 more
doaj   +2 more sources

Survival after multiple in-hospital cardiac arrests due to severe amitriptyline poisoning– a case report [PDF]

International Journal of Emergency Medicine
Background Amitriptyline, a classic tricyclic antidepressant, can produce toxic effects ranging from mild antimuscarinic symptoms to severe cardiotoxicity due to sodium channel blockade. In severe cases, toxicity may rapidly progress to cardiac arrest if
Amanuel Dagabas Wakoya, Tadesse G. Asenabeto, Hawi D. Moti, Negash B. Bayu, Fenta Wondimneh, Abebe D. Ayinalem, Alemu B. Mesekere, Ayto A. Negash, Tiliksew A. Tesfaw   +8 more
doaj   +2 more sources

Effectiveness of Genotype-Specific Tricyclic Antidepressant Dosing in Patients With Major Depressive Disorder

JAMA Network Open, 2023
Key Points Question Does pharmacogenetics-informed (CYP2D6 and CYP2C19 genotypes) dosing of tricyclic antidepressants result in faster attainment of therapeutic plasma concentrations, higher effectiveness, and fewer and less severe adverse effects ...
C. Vos, S. T. ter Hark, A. Schellekens, J. Spijker, A. van der Meij, A. Grotenhuis, Raluca Mihăescu, W. Kievit, R. Donders, R. Aarnoutse, M. Coenen, J. Janzing   +11 more
semanticscholar   +1 more source

Tricyclic Cell-Penetrating Peptides for Efficient Delivery of Functional Antibodies into Cancer Cells

Nature Chemistry, 2021
The intracellular environment hosts a large number of cancer- and other disease-relevant human proteins. Targeting these with internalized antibodies would allow therapeutic modulation of hitherto undruggable pathways, such as those mediated by protein ...
O. Tietz, Fernando Cortezon-Tamarit, R. Chalk, S. Able, K. Vallis   +4 more
semanticscholar   +1 more source

The Brugada Type 1 Electrocardiogram and Ventricular Tachycardia With High-Dose Amitriptyline

JACC: Case Reports, 2021
A 32-year-old woman with anorexia nervosa experienced ventricular tachycardia while on therapeutic-dose amitriptyline despite normal blood tests, imaging, and intracardiac recordings.
Ji-Jian Chow, MRCP, Nandita Kaza, MBChB, Amanda Varnava, MD   +2 more
doaj   +1 more source

Structure-activity relationship analysis and molecular structure construction of fused tricyclic energetic molecules containing flexible ring

Energetic Materials Frontiers, 2023
A simple, mild and efficient method was proposed to construct fused tricyclic skeletons based on Mannich reaction. This work not only develops a new method to construct the tricyclic skeletons effectively, but also provides a new insight into the fused ...
Jun-hao Shi, Hong-lei Xia, Si-wei Song, Si-tong Chen, Zi-wu Cai, Yu-teng Cao, Wen-quan Zhang   +6 more
doaj   +1 more source

Fixed Points Results for Various Types of Tricyclic Contractions

Axioms, 2021
In this paper, we introduce four new types of contractions called in this order Kanan-S-type tricyclic contraction, Chattergea-S-type tricyclic contraction, Riech-S-type tricyclic contraction, Cirić-S-type tricyclic contraction, and we prove the ...
Mustapha Sabiri, Abdelhafid Bassou, Jamal Mouline, Taoufik Sabar   +3 more
doaj   +1 more source

EXTREMAL IOTA ENERGY OF A SUBCLASS OF TRICYCLIC DIGRAPHS AND SIDIGRAPHS [PDF]

Matrix Science Mathematic, 2018
The iota energy of an n-vertex digraph D is defined by Ec (𝐷) = ∑ 􀀀1 |Im(𝑧 k)|, where z1, . . ., zn are eigenvalues of D and Im(zk) is the imaginary part of eigenvalue zk . The iota energy of an n-vertex sidigraph can be defined analogously.
Fareeha Jamal, Mehtab Khan
doaj   +1 more source