Results 191 to 200 of about 145,419 (376)

Go for Gold: Development of a Scalable Synthesis of [1‐(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

ChemistryOpen, EarlyView.
[1‐(Ethoxycarbonyl)cyclopropyl] triphenylphosphonium tetrafluoroborate is a limiting key reagent for synthesis of the tricyclic 5,6‐dihydropyrimido[5,4‐e]indolizine and related scaffolds, which are central to First‐in‐Class covalent inhibitors of the protein kinase monopolar spindle 1/threonine tyrosine kinase (TTK).
Leon Rebhan, Rebekka Fürst, Dieter Schollmeyer, Ricardo A. M. Serafim, Matthias Gehringer   +4 more
wiley   +1 more source

Evolving Treatment Strategies for Neuropathic Pain: A Narrative Review. [PDF]

Medicina (Kaunas)
Kaye AD, Armistead G, Amedio LS, Manthei ME, Ahmadzadeh S, Bernhardt B, Shekoohi S.   +6 more
europepmc   +1 more source

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, EarlyView.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source

Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors. [PDF]

Korean J Physiol Pharmacol
Jeong B, Chung JY, Jun JY, Hong C.
europepmc   +1 more source

Behavioral-pharmacological studies on doxepin, a tricyclic psychotropic agent

, 1972
Sakutaro Tadokoro
openalex   +2 more sources

Selektive Metallierung von BicycIo[3.2.1]octa-2,6-dien, II Distannylierte Derivate und stannylierte tricyclische Sekundärprodukte / Selective Metalation of Bicyclo[3.2.1]octa-2,6-diene, II Distannylated Derivatives and Stannylated Tricyclic Secondary Products [PDF]

, 1988
Norbert Hertkorn, Frank H. Köhler
openalex   +1 more source

Tricyclics and SSRIs [PDF]

British Journal of Psychiatry, 1996
R J Bowskill, P K Bridges
openaire   +2 more sources

Scenting the Hedonic Connection: Exploring the Impact of Subjective Olfactory Dysfunction on Depressive Symptoms

PsyCh Journal, EarlyView.
ABSTRACT Olfaction, often regarded as a unique chemical sensation, plays a pivotal role in shaping our quality of life and mental well‐being. Numerous studies have highlighted the significant relationship between olfactory function and depressive symptoms.
Zihan Ni, Ye Liu, Laiquan Zou, Qidong Zhang, Wu Fan, Chao Yan   +5 more
wiley   +1 more source

Hypotension after anesthesia induction in patients taking tricyclic antidepressants-A case series. [PDF]

Acta Anaesthesiol Scand
Lodsgaard M, Melchiors BB, Krøigaard M, Garvey LH.   +3 more
europepmc   +1 more source

Effects of tricyclic antidepressants on tetrabenazine-induced depletion of brain monoamines in rats

, 1979
Toshio Yoshizaki, Kanya Tonda
openalex   +1 more source