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Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
Journal of Medicinal Chemistry, 2013 B. Johns, T. Kawasuji, J. Weatherhead, T. Taishi, D. Temelkoff, H. Yoshida, T. Akiyama, Y. Taoda, H. Murai, R. Kiyama, M. Fuji, N. Tanimoto, J. Jeffrey, S. Foster, T. Yoshinaga, T. Seki, Masanori Kobayashi, A. Sato, Matthew N. R. Johnson, E. Garvey, T. Fujiwara +20 moresemanticscholar +1 more sourceCarbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles.
Journal of Medicinal Chemistry, 2013 T. Kawasuji, B. Johns, H. Yoshida, J. Weatherhead, T. Akiyama, T. Taishi, Y. Taoda, Minako Mikamiyama-Iwata, H. Murai, R. Kiyama, M. Fuji, N. Tanimoto, T. Yoshinaga, T. Seki, Masanori Kobayashi, A. Sato, E. Garvey, T. Fujiwara +17 moresemanticscholar +1 more source
