Results 31 to 40 of about 145,419 (376)

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources

Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]

, 2020
Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie, Gerlach, Ferdinand M, Glasziou, Paul P, Gonzalez-Gonzalez, Ana Isabel, Harder, Sebastian, Muth, Christiane, Nguyen, Truc Sophia, Pilz, Maximilian, Seide, Svenja E, Thomas, Elizabeth T   +9 more
core   +1 more source

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R., Drake-Holland, A.J., Noble, M.   +2 more
core   +1 more source

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

Molecules, 2013
In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules.
Giorgio Chelucci, Gérard A. Pinna, Giovanni Loriga, Giansalvo Pinna   +3 more
doaj   +1 more source

Structure-activity relationship analysis and molecular structure construction of fused tricyclic energetic molecules containing flexible ring

Energetic Materials Frontiers, 2023
A simple, mild and efficient method was proposed to construct fused tricyclic skeletons based on Mannich reaction. This work not only develops a new method to construct the tricyclic skeletons effectively, but also provides a new insight into the fused ...
Jun-hao Shi, Hong-lei Xia, Si-wei Song, Si-tong Chen, Zi-wu Cai, Yu-teng Cao, Wen-quan Zhang   +6 more
doaj  

Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides

Molecules, 2010
The palladium-catalyzed hydroarylation of N-methyl-substituted tricyclic imides was studied in order to find a new stereoselective access to a series of new exo-aryl(hetaryl)-substituted tricyclic N-methylimides.
Gokce Goksu, Nuket Ocal, Dieter E. Kaufmann   +2 more
doaj   +1 more source

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines

Molecules, 2022
A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported.
Kaikai Wang, Yanli Li, Wei Zhang, Rongxiang Chen, Xueji Ma, Mingyue Wang, Nan Zhou   +6 more
doaj   +1 more source

Tricyclic antidepressants for preventing migraine in adults

Medicine, 2017
Background: Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention.
Xiao-min Xu, Yang Liu, Mei-Xue Dong, De-zhi Zou, Youdong Wei   +4 more
semanticscholar   +1 more source

Oxygen-Induced Dimerization of Alkyl-Manganese(II) 2,6-Bisiminopyridine Complexes: Selective Synthesis of a New Ditopic NNN-Pincer Ligand [PDF]

, 2016
The outcome of the reaction of manganese(II) dialkyls with 2,6-bisiminopyridine (BIP) ligands is dramatically altered by the presence of very small amounts of oxygen (< 0.5 mol %), leading to binuclear species.
Cámpora Pérez, Juan, Melero, Cristobal, Palma, Pilar, Rodríguez Delgado, Antonio, Sandoval, John J., Álvarez González, Eleuterio   +5 more
core   +4 more sources

Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines

Angewandte Chemie, EarlyView.
A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao, Mengping Zhu, Pengyang He, Qigui Nie, Yangfeng Li, Gong Zhang, Yizhou Li   +6 more
wiley   +2 more sources