Results 41 to 50 of about 145,419 (376)
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Angewandte Chemie, EarlyView.Catalyst screening without catalysis. By combining cyclic voltammetry and DFT calculations we were able to identify a highly active catalyst for the radical arylation of epoxides without performing any reactions. The prevention of chloride binding that leads to catalyst inhibition was established as the key structural feature.
Niklas Schmickler +6 more
wiley +2 more sources
Molecules, 2023 3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades ...
Liangxin Fan +6 more
doaj +1 more source
Tricyclic and related drugs for nocturnal enuresis in children.
Cochrane Database of Systematic Reviews, 2016 BACKGROUND Enuresis (bedwetting) affects up to 20% of five year-olds and 2% of adults. Although spontaneous remission often occurs, the social, emotional and psychological costs can be great. Tricyclics have been used to treat enuresis since the 1960s.
Patrina H. Y. Caldwell +2 more
semanticscholar +1 more source
Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups
Angewandte Chemie, EarlyView.Use of enolate chemistry to functionalise amino acids with β‐heteroatom side‐chains (serine, cysteine, threonine, etc.) is hampered by β‐elimination. We show that α‐arylation can be achieved by incorporating the side chain into a saturated heterocycle, making the unwanted elimination a disfavoured 5‐endo‐trig reaction.
Ömer Taspinar +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.The total synthesis of isodaphlongamine H was accomplished by a lactam strategy. This strategy started with alkylation and N‐oxidation of a readily available chiral lactam. For the key functionalization of the amide carbonyl, an iridium‐catalyzed reductive [3 + 2] cycloaddition of the N‐hydroxylactam afforded the tricyclic isoxazolidine, which was ...
Sora Iwamoto +15 more
wiley +2 more sources
Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates [PDF]
, 2014 This tutorial review highlights the organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium/azolium enolates.
Morrill, Louis C., Smith, Andrew D.
core +1 more source
Angewandte Chemie, EarlyView.A highly enantioselective iridium‐catalyzed hydroarylation of allene‐tethered pyrroles and indoles that provides access to relevant heterocyclic systems bearing vinyl‐substituted 3ry or 4ry stereocenters is reported. Its synthetic potential was exemplified with a very short, highly enantioselective formal synthesis of (+)‐Rhazinilam, whereas DFT ...
Andrés Arribas +4 more
wiley +2 more sources
Molecules, 2023 A practical method was developed for the convenient synthesis of isoxazole-fused tricyclic quinazoline alkaloids. This procedure accesses diverse isoxazole-fused tricyclic quinazoline alkaloids and their derivatives via intramolecular cycloaddition of ...
Zhuo Wang +9 more
doaj +1 more source
Angewandte Chemie, EarlyView.Carbatranes and anionic pincer ligands were self‐assembled via one‐pot C─F or C─O bond cleavage and the formation of C─O, C─N, or C─C bonds, forming ligand architectures inaccessible by common synthetic methods. This approach allowed to build a customizable library of nickel catalysts for light‐induced C─H bond trifluoromethylation.
Aleksandr Sorvanov +5 more
wiley +2 more sources