Results 51 to 60 of about 145,419 (376)
Silver(I) triflate-catalyzed protocol for the post-ugi synthesis of spiroindolines
, 2019 A silver(I) triflate-catalyzed protocol for the post-Ugi synthesis of tetracyclic spiroindolines has been developed. The protocol worked best for indole-3-carbaldehyde-derived Ugi adducts obtained using anilines and 3-aryl propiolic acids.
Hasan, Muhammad +6 more
core +1 more source
Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids [PDF]
, 2008 Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in ...
Bagdanoff, Jeffrey T. +5 more
core +2 more sources
Advanced Science, EarlyView.KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma +9 more
wiley +1 more source
Development of a Vinylated Cyclic Allene: A Fleeting Strained Diene for the Diels–Alder Reaction
Angewandte Chemie, EarlyView.A strain‐promoted Diels–Alder reaction of the vinylated cyclic allene, a highly reactive strained all‐carbon diene, was developed. Activation of the Kobayashi‐type precursor with fluoride ion generated the vinyl cyclic allene, which was trapped by dienophiles to produce decalin derivatives under mild conditions.
Haruki Mizoguchi +4 more
wiley +2 more sources
Acta Crystallographica Section E: Crystallographic Communications, 2021 The molecule of the title compound, C15H15Br2NO3, comprises a fused tricyclic system consisting of two five-membered rings (cyclopentane and tetrahydrofuran) and one six-membered ring (tetrahydropyridinone).
Dmitriy F. Mertsalov +6 more
doaj +1 more source
Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification [PDF]
, 2015 Here we report a unique method of ribosomally synthesizing fused tricyclic peptides. Flexizyme-assisted in vitro translation of a linear peptide with the N-terminal chloroacetyl group and four downstream cysteines followed by the addition of 1,3,5-tris ...
Bashiruddin, Nasir Kato +2 more
core +1 more source
Advanced Energy Materials, EarlyView.Asymmetric Y‐acceptor BTQT‐4F featuring innovative fused‐imidazole central linkage, is successfully developed by 2D π‐expansion strategy. The decent power conversion efficiencies (PCEs) of 18.22% and 19.40% are achieved in the PM6:BTQT‐4F binary and PM6:BTP‐eC9:BTQT‐4F ternary organic solar cells (OSCs), respectively.
Huihuang Zhang +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar +15 more
wiley +2 more sources
Severe Amitriptillin Intoxication Treated with Intravenous Lipid Emulsion
Journal of Pediatric Emergency and Intensive Care Medicine, 2021 Intoxication with tricyclic antidepressant drugs causes serious toxic findings even at low doses. Despite common use of the antidepressant drugs, there are no randomized controlled trials about treatments in tricyclic antidepressant drug intoxication ...
Ayyüce Ünlü +4 more
doaj +1 more source