Results 61 to 70 of about 109,999 (323)

The synergistic effect of anticholinergic burden and depression on fall risk in older persons

British Journal of Clinical Pharmacology, EarlyView.
Aims Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent.
Raymond Salet, Nathalie van der Velde, Didi Rhebergen, Bob van de Loo, Lotta Seppala, Natasja M. van Schoor, Bruno Stricker, Marieke Henstra   +7 more
wiley   +1 more source

9,10-Dioxa-1,2-diaza-anthracene derivatives from tetrafluoropyridazine

Beilstein Journal of Organic Chemistry, 2010
Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the ...
Graham Pattison, Graham Sandford, Dmitrii S. Yufit, Judith A. K. Howard, John A. Christopher, David D. Miller   +5 more
doaj   +1 more source

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported.
Lingling Yang, Feng Chen, Cheng Gao, Jiabao Chen, Junyan Li, Siyan Liu, Yuanyuan Zhang, Zhouyu Wang, Shan Qian   +8 more
doaj   +1 more source

Risk of suicide during treatment with venlafaxine, italopram, fluoxetine, and dothiepin : retrospective cohort study [PDF]

, 2006
Objective To compare the risk of suicide in adults usingthe antidepressant venlafaxine compared with citalopram, fluoxetine, and dothiepin. Design Retrospective cohort study. Setting UK General Practice Research Database. Participants 219 088 patients,
Andrews, Elizabeth, Mines, Daniel, Roskell, Neil, Rubino, Annalisa, Tennis, Pat, Weich, Scott   +5 more
core   +2 more sources

Trends in analgesia prescribing in primary care in Ireland and England between 2014 and 2022: A repeated cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson, Michelle Flood, Brian MacKenna, Emma Wallace, Fiona Boland, Ciara Kirke, Mary E. Walsh, Tom Fahey, Frank Moriarty   +8 more
wiley   +1 more source

Chewing the fat: A case report on intravenous lipid emulsion to reverse cardiotoxicity from intentional amitriptyline overdose.

African Journal of Emergency Medicine, 2012
Introduction: Tricyclic antidepressant overdoses are a common presenting problem to emergency centres in South Africa. Case history: A 20-year-old female was brought to the emergency centre in status epilepticus due to tricyclic antidepressant toxicity ...
J. Hellig, I. Von Watzdorf, S. Lahri, K. Vallabh, R.L. Allgaier   +4 more
doaj   +1 more source

Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

Systematic Reviews, 2021
Background Major depressive disorder is a common psychiatric disorder causing great burden on patients and societies. Tricyclic antidepressants are frequently used worldwide to treat patients with major depressive disorder.
Caroline Kamp Jørgensen, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen   +8 more
doaj   +1 more source

Graphs with 3-rainbow index $n-1$ and $n-2$ [PDF]

, 2013
Let $G$ be a nontrivial connected graph with an edge-coloring $c:E(G)\rightarrow \{1,2,\ldots,q\},$ $q\in \mathbb{N}$, where adjacent edges may be colored the same. A tree $T$ in $G$ is a $rainbow tree$ if no two edges of $T$ receive the same color.
Li, Xueliang, Yang, Kang, Zhao, Yan
core  

Topical treatment of peripheral neuropathic pain: applying the evidence [PDF]

, 2017
Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events.
Cruccu, Giorgio, Sommer, Claudia
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source