Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
The Pan African Medical Journal, 2012 BACKGROUND: Pethidine, an opioid analgesic is used for pain management. Clomipramine a tricyclic antidepressant primarily used for mood management is also used to treat pain.
Hellen N Kariuki +2 more
doaj +1 more source
ST-T segment changes in patients with tricyclic antidepressant poisoning
Journal of Research in Pharmacy Practice, 2013 Objective: Tricyclic antidepressant (TCA) poisoning is among highly prevalent and potentially dangerous toxicities. ST-T changes are observed in the electrocardiogram (ECG) of most of TCA poisoned patients.
Farzad Gheshlaghi +5 more
doaj +1 more source
Rabdomiolise como manifestacao de intoxicacao por clomipramina [PDF]
, 2013 CONTEXT:Tricyclic antidepressive agents are widely used in suicide attempts and present a variety of deleterious effects. Rhabdomyolysis is a rare complication of such poisoning.CASE REPORT:A 55-year-old woman ingested 120 pills of 25 mg clomipramine in ...
Góis, Aécio Flávio Teixeira de +1 more
core +1 more source
Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database [PDF]
, 2016 Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depression.
Arthur, Antony +5 more
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The Egyptian Journal of Otolaryngology, 2019 Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride ...
Tamer A. Abo El Ezz +2 more
doaj +1 more source
Tricyclic antidepressant poisoning
Cleveland Clinic Journal of Medicine, 2000 Tricyclic antidepressant poisoning causes predictable electrocardiographic abnormalities and can be lethal. Cardiac arrhythmias, hypotension, seizures, and coma are common. Sodium bicarbonate is still considered the treatment of choice for severe toxicity, although a variety of supportive measures may be taken.
openaire +2 more sources
Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]
, 2004 Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C. +2 more
core +1 more source
Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
core +4 more sources
Antidepressant efficacy and side effect burden: an updated guide for clinicians
Drugs in Context, 2020 Antidepressant treatment has been evolving and changing since the 1950s following the discovery of the classic antidepressant treatments including tricyclic antidepressants and monoamine oxidase inhibitors.
Tatum Kutzer +4 more
doaj +1 more source