Results 41 to 50 of about 39,692 (259)

Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort

BMC Medicine, 2017
Background Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a ...
Isabelle Carrière, Joanna Norton, Amandine Farré, Marilyn Wyart, Christophe Tzourio, Pernelle Noize, Karine Pérès, Annie Fourrier-Réglat, Karen Ritchie, Marie Laure Ancelin   +9 more
doaj   +1 more source

Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose. Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE. Methods.
Ying Wang, Zhikang Ye, Lihong Liu, Xiangli Cui   +3 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Antinociceptive potentiation of pethidine (demerol) by clomipramine in the late phase of formalin test in mice

The Pan African Medical Journal, 2012
BACKGROUND: Pethidine, an opioid analgesic is used for pain management. Clomipramine a tricyclic antidepressant primarily used for mood management is also used to treat pain.
Hellen N Kariuki, Titus I Kanui, Paul G Kioy   +2 more
doaj   +1 more source

ST-T segment changes in patients with tricyclic antidepressant poisoning

Journal of Research in Pharmacy Practice, 2013
Objective: Tricyclic antidepressant (TCA) poisoning is among highly prevalent and potentially dangerous toxicities. ST-T changes are observed in the electrocardiogram (ECG) of most of TCA poisoned patients.
Farzad Gheshlaghi, Mozhgan Karbalayi Mehrizi, Ahmad Yaraghi, Ali Mohammad Sabzghabaee, Forough Soltaninejad, Nastaran Eizadi-Mood   +5 more
doaj   +1 more source

Rabdomiolise como manifestacao de intoxicacao por clomipramina [PDF]

, 2013
CONTEXT:Tricyclic antidepressive agents are widely used in suicide attempts and present a variety of deleterious effects. Rhabdomyolysis is a rare complication of such poisoning.CASE REPORT:A 55-year-old woman ingested 120 pills of 25 mg clomipramine in ...
Góis, Aécio Flávio Teixeira de, Santana, Nathalie Oliveira De   +1 more
core   +1 more source

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database [PDF]

, 2016
Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depression.
Arthur, Antony, Coupland, Carol, Hill, Trevor, Hippisley-Cox, Julia, Moore, Michael, Morriss, Richard K.   +5 more
core   +2 more sources

Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus

The Egyptian Journal of Otolaryngology, 2019
Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride ...
Tamer A. Abo El Ezz, Fathy N. Fattoh, Tahany Rabie   +2 more
doaj   +1 more source

Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]

, 2015
Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian, Păunică, Ioana, Scutari, Corina, Ștefănescu, Emil   +3 more
core   +4 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source