Results 121 to 130 of about 105,083 (249)

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Characterization of the Lysophosphatidic Acid Receptor 5 Antagonist RLPA‐76 as a Novel Analgesic in Male Rats and Mice

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Clinically used analgesics such as gabapentinoids and opioids have limited efficacy and adverse effects like abuse liability, and there is a dire need for novel analgesics with improved safety profiles. Since lysophosphatidic acid can induce neuropathic pain in rodents, LPA receptor antagonists have been investigated as potential analgesics ...
Kristen L. Woodhouse, Maowei Wang, Sai Ganesh Balaji Venkata Anupindi, Olatunbosun Adeoke, Dehui Zhang, Yanan Zhang, Jun‐Xu Li   +6 more
wiley   +1 more source

Sphenopalatine Ganglion-Targeted Interventions for Trigeminal Autonomic Cephalgias: A Scoping Review

This will be a scoping review aimed at characterizing the currently available evidence for sphenopalatine ganglion-targeted interventions for the treatment of trigeminal autonomic cephalgias.
Sean Kelleher, Anthony Yulin Chen
core   +1 more source

Computed tomography reveals the endocranial anatomy of Crocodylia: Implications for phylogenetic relationships and ecomorphological convergence across Crocodylomorpha

Journal of Anatomy, Volume 249, Issue 6, Page 1368-1427, December 2026.
The evaluation of the endocranial anatomy of 43 crocodylian species reveals several differences, including variation in the curvature of the encephalic endocast, the size of the endosseous labyrinth and paratympanic sinuses, and the presence of additional snout sinuses.
Paul M. J. Burke, Philip D. Mannion
wiley   +1 more source

Cranial anatomy of a Late Cretaceous aspidorhynchid fish (Neopterygii: Aspidorhynchiformes) from Alberta, Canada

The Anatomical Record, Volume 309, Issue 11, Page 3123-3136, November 2026.
Abstract Belonostomus longirostrisis was named for an isolated jaw fragment from freshwater Upper Cretaceous (Campanian) sediments of the Dinosaur Park Formation of Alberta, Canada. Following the description of the Albertan species, numerous isolated cranial and postcranial elements have been collected from the Dinosaur Park Formation and assigned to B.
Mondo Miyazato, Luke E. Nelson, Joshua A. Doyon, Donald B. Brinkman, Alison M. Murray   +4 more
wiley   +1 more source

Intraskeletal Pathway of the Trigeminal Nerve in Modern Bird Beak: 3D Comparative Anatomy Using the diceCT Method

Journal of Morphology, Volume 287, Issue 11, November 2026.
We investigated the intraskeletal pathway of the trigeminal nerve in Aves, using diffusible iodine‐enhanced contrast‐enhanced computer tomography. Among the examined species, the main nerve pathways of the ophthalmic, maxillary, and mandibular nerves were highly conserved, although the ophthalmic nerve pathway around the external naris differed in ...
Noriyuki Wakimizu, Takanobu Tsuihiji
wiley   +1 more source

Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine

, 2009
Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of ...
H-J Cho (13635067), V Staikopoulos (19457149), John Furness (13070439), EA Jennings (19457155)   +3 more
core  

Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion

, 1993
The cellular localization of mRNA for neurotrophin-4 (NT-4), a novel neurotrophic factor, in the developing whisker follicles and skin of the embryonic rat is demonstrated by in situ hybridization.
Patrik Ernfors, Nancy Y. Ip, Ip, Nancy Y., Ibáñez, Carlos F., Yancopoulos, George D., Arenas, Ernest, Carlos F. Ibáñez, Håkan Persson, Ernfors, Patrik, George D. Yancopoulos, Timmusk, Tõnis, Persson, Håkan, Tõnis Timmusk, Ernest Arenas, YANCOPOULOS, GD, ARENAS, E, IP, NY, ERNFORS, P, PERSSON, H, IBANEZ, CF, TIMMUSK, T   +20 more
core   +1 more source

Molecular Epidemiology of Varicella‐Zoster Virus Among Patients From Two French Tertiary Care Hospitals: Differential Distribution of Clades According to Demographic Criteria

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT Varicella‐zoster virus (VZV) nomenclature currently recognizes seven established clades (designated 1–6 and 9). A geographical segregation of VZV clades has been shown, with Clades 1, 3, and 6 predominating in Europe, Americas, and Australia, Clade 2 in Japan and East‐Asia, and Clades 4 and 5 in Asia and Africa. This distribution of VZV clades
José Fernandez, Melinda Cheminet, Lucie Mazarguil, Mathilde Gay, Antoine Fauchois, Camille Tumiotto, Sonia Burrel, David Boutolleau   +7 more
wiley   +1 more source

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

The Journal of Headache and Pain
Background Triptans are potent 5-HT1B/1D/1F receptor agonists used in migraine therapy, thought to act through peripheral mechanisms. It remains unclear whether triptans cross the blood-brain barrier (BBB) sufficiently to stimulate central 5-HT1B/1D/1F ...
Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan   +5 more
doaj   +1 more source