Results 241 to 250 of about 1,572,766 (300)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Effect of Mirror Therapy on Post-Needling Pain Following Deep Dry Needling of Myofascial Trigger Point in Lateral Elbow Pain: Prospective Controlled Pilot Trial. [PDF]

open access: yesJ Clin Med
Martín Pérez SE   +12 more
europepmc   +1 more source

Myofascial Trigger Points

Anesthesiology Clinics, 2007
Painful conditions of the musculoskeletal system, including myofascial pain syndrome, constitute some of the most important chronic problems encountered in a clinical practice. A myofascial trigger points is a hyperirritable spot, usually within a taut band of skeletal muscle, which is painful on compression and can give rise to characteristic referred
Elizabeth Demers, Lavelle   +2 more
openaire   +3 more sources

Latent Myofascial Trigger Points

Current Pain and Headache Reports, 2011
A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination. Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle ...
Ge, Hong-You, Arendt-Nielsen, Lars
openaire   +3 more sources

Myofascial Pain Syndromes–Trigger Points

Journal of Musculoskeletal Pain, 2004
Four articles this quarter present major progress in new experimental data. Hou et al. demonstrated in rabbits that motor endplate potentials [spontaneous electrical activity] of trigger spots are partially dependent on increased calcium channel permeability. Delaney et al.
David G. Simons, Jan Dommerholt
openaire   +1 more source

Replication stress as a trigger for cell extrusion

Nature Reviews Molecular Cell Biology, 2021
exaly  

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