Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Clinical application of acupuncture myofascial trigger points in the treatment of postherpetic neuralgia and analysis of influencing factors. [PDF]
Medicine (Baltimore)Bi H, Luo C, Bu B.
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Anatomical Investigation of the Gluteus Medius Muscle Innervation and Its Topographical Correspondence With Myofascial Trigger Points. [PDF]
Biomed Res IntPinheiro RP +7 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frequency of Trigger Points in Lower Extremity Muscles Among Runners with Plantar Fasciitis
Journal Riphah College of Rehabilitation SciencesBACKGROUND: Plantar fasciitis is a condition used to describe heel pain brought on by excessive stress on the plantar aspect of the foot. Trigger points are extremely sensitive spots found in tense muscular bands.
Tayyaba Akbar +2 more
doaj
Trigger Points of Necroptosis (RIPK1, RIPK3, and MLKL)-Promising Horizon or Blind Alley in Therapy of Colorectal Cancer? [PDF]
Int J Mol SciSokołowski M, Butrym A.
europepmc +1 more source
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 2014 Masahiro MORIMOTO, Toru SHIRAI
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Shoulder kinematic and muscle recruitment pattern changes in upper trapezius myofascial trigger points: a controlled observational study. [PDF]
BMC Musculoskelet DisordRahmati M, Bahrpeyma F, Ashtiani MN.
europepmc +1 more source