Results 111 to 120 of about 229,067 (324)

Use of lipid‐lowering therapies in patients with chronic kidney disease and atherosclerotic cardiovascular disease: 2‐year results from Getting to an imprOved Understanding of Low‐Density lipoprotein cholesterol and dyslipidemia management (GOULD)

Clinical Cardiology, Volume 45, Issue 12, Page 1303-1310, December 2022., 2022
Abstract Background Chronic kidney disease (CKD) is a known risk factor of atherosclerotic cardiovascular disease (ASCVD). Per the 2018 American Heart Association/American College of Cardiology cholesterol guidelines, high‐risk ASCVD patients with CKD and low‐density lipoprotein cholesterol (LDL‐C) levels ≥ $\ge $ 70 mg/dL should take a high‐intensity ...
Aleesha Shaik, Mikhail Kosiborod, James A. de Lemos, Qi Gao, Katherine E. Mues, Shushama Alam, Deepak L. Bhatt, Christopher P. Cannon, Christie M. Ballantyne, Robert S. Rosenson, The GOULD Investigators   +10 more
wiley   +1 more source

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue

Advanced Science, EarlyView.
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao, Ben‐Chi Zhao, Hui‐Lin Li, Ying Liu, Bei Wang, An‐Qi Li, Tian‐Shu Zeng, Hannah Xiaoyan Hui, Jia Sun, Domagoj Cikes, Nele Gheldof, Jorg Hager, Jian‐Xun Mi, D. Ross Laybutt, Yin‐Yue Deng, Yan‐Chuan Shi, G. Gregory Neely, Qiao‐Ping Wang   +17 more
wiley   +1 more source

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother.
Fabia de Oliveira Andrade, Vivek Verma, Leena Hilakivi‐Clarke   +2 more
wiley   +1 more source

The Rate of Absorption of Synthetic Triglycerides in the Rat [PDF]

, 1940
Harry J. Deuel, Lois F. Hallman
openalex   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Secondary Phenotype Analysis in Ascertained Family Designs: Application to the Leiden Longevity Study [PDF]

arXiv, 2016
The case-control design is often used to test associations between the case-control status and genetic variants. In addition to this primary phenotype a number of additional traits, known as secondary phenotypes, are routinely recorded and typically associations between genetic factors and these secondary traits are studied too.
arxiv  

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Women with type 1 diabetes (T1D) are more susceptible than men to cardiovascular disease (CVD). Signs of increased risk may already appear among adolescent girls. Objectives We explored the contribution of body composition to the development of CVD risk factors among youth with T1D.
Avivit Brener, Sandy Hamama, Hagar Interator, Asaf Ben Simon, Irina Laurian, Anna Dorfman, Efrat Chorna, Michal Yackobovitch‐Gavan, Asaf Oren, Ori Eyal, Yael Lebenthal   +10 more
wiley   +1 more source

Enhancing Metabolic Syndrome Prediction with Hybrid Data Balancing and Counterfactuals [PDF]

arXiv
Metabolic Syndrome (MetS) is a cluster of interrelated risk factors that significantly increases the risk of cardiovascular diseases and type 2 diabetes. Despite its global prevalence, accurate prediction of MetS remains challenging due to issues such as class imbalance, data scarcity, and methodological inconsistencies in existing studies.
arxiv  

High-dimensional confounding adjustment using continuous spike and slab priors [PDF]

arXiv, 2017
In observational studies, estimation of a causal effect of a treatment on an outcome relies on proper adjustment for confounding. If the number of the potential confounders ($p$) is larger than the number of observations ($n$), then direct control for all potential confounders is infeasible.
arxiv