Results 11 to 20 of about 487,773 (305)

Triglyceride and Triglyceride-Rich Lipoproteins in Atherosclerosis

Frontiers in Molecular Biosciences, 2022
Cardiovascular disease (CVD) is still the leading cause of death globally, and atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol (LDL-C) is a strong causal factor of atherosclerosis. However, the first-line lipid-lowering drugs, statins, only reduce approximately 30% of the CVD risk.
Bai-Hui Zhang, Fan Yin, Ya-Nan Qiao, Shou-Dong Guo   +3 more
openaire   +3 more sources

Triglyceride-Mimetic Structure-Gated Prodrug Nanoparticles for Smart Cancer Therapy

, 2021
Off-target drug release and insufficient drug delivery are the main obstacles for effective anticancer chemotherapy. Prodrug-based self-assembled nanoparticles bioactivated under tumor-specific conditions are one of the effective strategies to achieve on-
Bingjun Sun (2920098), Qing Ye (90197), Ken-ichiro Kamei (1476706), Shuang Zhou (339964), Jin Sun (117866), Wenxue Liu (6877754), Chutong Tian (5977481), Shunzhe Zheng (11631616), Mengchi Sun (2617605), Jingjing Guo (393650), Yifan Miao (5514839), Zhonggui He (1329060)   +11 more
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Triglycerides and Cardiovascular Risk [PDF]

Current Cardiology Reviews, 2009
In 1996 a meta-analysis was published showing that an increase in plasma triglyceride (TG) levels was associated with an increase in CHD risk, even after adjustment for high density lipoprotein cholesterol (HDL-C) levels. Very recently, two studies were published that further extent the early observation and showed the importance of nonfasting plasma ...
Harchaoui, K. E. L., Visser, M. E., Kastelein, J. J. P., Stroes, E. S., Dallinga-Thie, G. M.   +4 more
openaire   +2 more sources

Triglyceride-Tethered Membrane Lipase Sensor

, 2023
Sensors that can quickly measure the lipase activity from biological samples are useful in enzyme production and medical diagnostics. However, current lipase sensors have limitations such as requiring fluorescent labels, pH control of buffer vehicles, or
Charles G. Cranfield (3191211), Upeksha Mirissa Lankage (17343473), Samara Bridge (17343476), Stephen A. Holt (283442), Bruce Cornell (3191205)   +4 more
core   +1 more source

Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

, 2022
Background: Recent studies have suggested that triglyceride-glucose (TyG) index is an independent predictor of cardiovascular disease (CVD). However, the impact of long-term visit-to-visit variability in TyG index on the risk of CVD is not known.
X Guo (1378956), A Wang (4241158), F Qian (9854591), S Chen (5107745), Xia Li (9484709), S Wu (6794345), H Li (100694), P Wang (1542061), Y Zuo (9878198), X Tian (7942073)   +9 more
core   +1 more source

Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. [PDF]

, 2003
BACKGROUND: Triglyceride concentrations are raised in pregnancy and are considered a key fetal fuel. Several gene variants are known to alter triglyceride concentrations, including those in the Apolipoprotein E (ApoE), Lipoprotein Lipase (LPL), and most ...
Andrew T Hattersley, Beatrice Knight, Kirsten J Ward, Ward Kirsten J, Knight Beatrice, Hattersley, Andrew T, Ward, Kirsten J, Maurice B Salzmann, Timothy M Frayling, Frayling, Timothy M, Beverley Shields, Shields, Beverley, Salzmann Maurice B, Hattersley Andrew T, Shields Beverley, Frayling Timothy M, Knight, Beatrice, Salzmann, Maurice B   +17 more
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Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source

Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis

Biomedicines, 2021
Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce ...
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu   +5 more
doaj   +1 more source

The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The level of plasma triglyceride is balanced by the rate of secretion into and clearance from the plasma. Tyloxapol (Triton WR1339) is a nonionic detergent that inhibits lipoprotein lipase and hence clearance of triglyceride from the ...
Mehdi Rasouli, Hanieh Tahmouri, Mahboobeh Mosavi-Mehr   +2 more
doaj   +1 more source

Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene

Journal of Lipid Research, 2002
Missense mutations in exon 5 of the LPL gene are the most common reported cause of LPL deficiency. Exon 5 is also the region with the strongest homology to pancreatic and hepatic lipase, and is conserved in LPL from different species. Mutant LPL proteins
Jonas Peterson, Amir F. Ayyobi, Yuanhong Ma, Howard Henderson, Manuel Reina, Samir S. Deeb, Silvia Santamarina-Fojo, Michael R. Hayden, John D. Brunzell   +8 more
doaj   +1 more source