Results 41 to 50 of about 516,686 (295)

Clinical and molecular characterization of familial chylomicronemia in Saudi patients: a retrospective study

Frontiers in Endocrinology
IntroductionFamilial chylomicronemia syndrome (FCS) is a severe type of hypertriglyceridemia (HTG). Despite its rarity, we have encountered more than 100 patients with FCS at our center. Therefore, we aimed to provide a useful resource for clinicians who
Abdullah Al-Ashwal, Manal AlHelal, Afaf AlSagheir, Areej Alfattani, Khushnooda Ramzan, Faiqa Imtiaz, Raghad Alhuthil   +6 more
doaj   +1 more source

Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2018
Pulmonary tuberculosis (TB) exhibits granulomatous inflammation, a site of controlling bacterial dissemination at the cost of host tissue damage. Intrigued by the granuloma type-dependent expression of inflammatory markers in TB, we sought to investigate
Neetika Jaisinghani, Neetika Jaisinghani, Stanzin Dawa, Stanzin Dawa, Kaurab Singh, Kaurab Singh, Ananya Nandy, Ananya Nandy, Dilip Menon, Dilip Menon, Purva Deepak Bhandari, Purva Deepak Bhandari, Garima Khare, Anil Tyagi, Anil Tyagi, Sheetal Gandotra, Sheetal Gandotra   +16 more
doaj   +1 more source

Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish

Frontiers in Endocrinology, 2020
Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues.
Xiao-Chen Yuan, Xiao-Chen Yuan, Xu-Fang Liang, Xu-Fang Liang, Wen-Jing Cai, Wen-Jing Cai, Ai-Xuan Li, Ai-Xuan Li, Dong Huang, Dong Huang, Shan He, Shan He   +11 more
doaj   +1 more source

INSIG1 influences obesity-related hypertriglyceridemia in humans [PDF]

, 2010
In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the ...
Carless, M., Blangero, J., Kissebah, A., Curran, J., Cole, R., Dyer, T. D., Curran, Joanne E., Carless, Melanie A., Olivier, M. (Michael), Dyer, T., Abraham, L., Moses, Eric, Martin, L. J. (Lisa J.), Gawrieh, S., Olivier, M., Zhang, Y., Baye, T., Smith, Edward M., Baye, T. M., Kissebah, Ahmed, Abraham, L. J., Moses, E. K. (Eric Keith), Martin, L., Smith, E.   +23 more
core   +1 more source

Triglyceride-inflammation score established on account of random survival forest for predicting survival in patients with nasopharyngeal carcinoma: a retrospective study

Frontiers in Immunology
ObjectiveThis study aimed to establish an effective prognostic model based on triglyceride and inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), to predict ...
Jun Li, Jun Li, Yinxin Ye, Yinxin Ye, Yonglin Cai, Huojin Ji, Huojin Ji, Weiling Qin, Weiling Qin, Yonglin Luo, Yonglin Luo, Xiaoying Zhou, Zhe Zhang, Xue Xiao, Bin Zhang   +14 more
doaj   +1 more source

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipaemia, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular ...
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai   +4 more
doaj   +1 more source

Structural investigations of the regio- and enantioselectivity of lipases [PDF]

, 1998
Although lipases are widely applied for the stereospecific resolution of racemic mixtures of esters, the atomic details of the factors that are responsible for their stereospecificity are largely obscure. We determined the X-ray structures of Pseudomonas
Dietmar A Lang, Dietmar A. Lang, Bauke W Dijkstra, Lang, Dietmar A., Dijkstra, Bauke W., Dijkstra, Bauke W.,, Bauke W. Dijkstra, Lang, Dietmar A.,   +7 more
core   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Triglyceride [PDF]

Circulation, 1998
The relation of serum TG concentrations and risk for CHD has been an issue of great interest and controversy. Unlike analyses with LDL-C and HDL-C, for which very strong and consistent relations with CHD risk have been demonstrated in observational and interventional studies, those with TG are ambiguous. Thus, TG represents a clinical conundrum: should
openaire   +1 more source