Results 81 to 90 of about 516,686 (295)
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Lipid Biomarkers for Amyotrophic Lateral Sclerosis
Frontiers in Neurology, 2019 Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease primarily characterized by the selective loss of upper and lower motor neurons. To date, there is still an unmet need for robust and practical biomarkers that could estimate the risk of ...
Jose-Luis González De Aguilar +1 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu +13 more
wiley +1 more source
Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing
Advanced Science, EarlyView.Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley +1 more source
Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design
Advanced Science, EarlyView.This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi +4 more
wiley +1 more source
, 1998 A relationship between postprandial lipaemia and coronary heart disease (CHD) was established as early as the 1950s. Since then, most attention has been paid to postprandial triglyceride-rich lipoproteins (TRLs) of intestinal origin, i.e.
Johan Björkegren (88391)
core +1 more source
Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention. [PDF]
Clin Pharmacol TherLow‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Fransquet PD +8 more
europepmc +2 more sources
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Lipase Based Biosensors for Triglyceride Determination
, 2016 A review of methods development in lipase based biosensor for triglyceride determination was briefly discussed. This review focuses on the basic principle of triglyceride biosensor that includes performances of triglyceride biosensor such as limit of ...
Zainiharyati Mohd Zain +2 more
core +2 more sources
Triglyceride-Glucose Index is a Reliable Predictor of Metabolic Disorder in Gallstones [PDF]
Objective: The risk of gallstones is increased in fatty liver, overweight, and metabolic syndrome. The hyperinsulinemic-euglycemic clamp method is considered the best method for insulin resistance (IR); but it is a time consuming and expensive procedure.
Zeynep ERGENÇ +3 more
core +1 more source