Results 181 to 190 of about 821,330 (390)

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

The structure of rat liver triglycerides [PDF]

, 1968
Sister P. M. Slakey, William E.M. Lands
openalex   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology.

Circulation Research, 2016
B. Nordestgaard
semanticscholar   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Direct Esterifi cation of Higher Fatty Acids with Glycerol VI. The Formation of Triglycerides

, 1941
Shigeto Kawai, Hiroshi Mori
openalex   +2 more sources

Polarization‐Sensitive Holotomography for Multidimensional Label‐Free Imaging and Characterization of Lipid Droplets in Cancer Cells

Advanced Science, EarlyView.
Polarization‐sensitive holotomography (PS‐HT) enables label‐free 3D imaging and quantitative analysis of lipid droplets by exploiting their intrinsic birefringence. Applied to prostate cell models, PS‐HT reveals glucose‐induced lipid accumulation in cancer cells and achieves near‐perfect classification of healthy and cancerous states.
Hossein Khadem, Maria Mangini, Maria Antonietta Ferrara, Anna Chiara De Luca, Giuseppe Coppola   +4 more
wiley   +1 more source

The Determination of Triglycerides in Plasma and Tissues

, 1968
Vishwanath M. Sardesai, Joan A. Manning
openalex   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

The Combined Effect of Aerobic Training and Vegetarian Diet on Lipid Profile in Adults: A Systematic Review and Meta-Analysis [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction: Exercise training and vegetarian diets have been accepted as suitable and non-pharmacological methods for improving lifestyle and mitigating obesity, and related metabolic diseases.
Fatemeh Kazeminasab
doaj