Results 101 to 110 of about 517,171 (297)

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

The effects of dietary intervention on HIV dyslipidaemia : a systematic review and meta-analysis [PDF]

, 2012
Background Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established. Methods We conducted a systematic search of electronic databases supplemented with manual searches and ...
Thomas, G. Neil, Yen-Fu Chen, Shahrad Taheri (57360), G. Neil Thomas (159433), Connock, Martin, Taheri, S., Connock Martin, Russell, Tracy, Tracy Russell, Thomas, G Neil, Shahrad Taheri, Clare Stradling, Clare Stradling (159408), Chen Yen-Fu, Connock, M., Thomas G. Neil, Chen, Yen-Fu, Chen, Y-F.‏‎, Martin Connock (159426), G Neil Thomas, Tracy Russell (159420), Russell Tracy, Yen-Fu Chen (159414), Chen, Yen-Fu; id_orcid, Martin Connock, Taheri, Shahrad, Stradling Clare, Taheri Shahrad, Stradling, Clare   +28 more
core   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Triglyceride-Catabolizing Lactiplantibacillus plantarum GBCC_F0227 Shows an Anti-Obesity Effect in a High-Fat-Diet-Induced C57BL/6 Mouse Obesity Model

Microorganisms
Given the recognized involvement of the gut microbiome in the development of obesity, considerable efforts are being made to discover probiotics capable of preventing and managing obesity.
Jinwook Kim, Seong-Gak Jeon, Min-Jung Kwak, So-Jung Park, Heeji Hong, Seon-Bin Choi, Ji-Hyun Lee, So-Woo Kim, A-Ram Kim, Young-Kyu Park, Byung Kwon Kim, Bo-Gie Yang   +11 more
doaj   +1 more source

Hypertriglyceridemia and preeclampsia: Its physiological role and up-to-date evidence [PDF]

MedUNAB, 2005
Preeclampsia is a disease with a highincidence for maternal and fetal morbidity and mortality, mainly indeveloping countries. Although its etiology remains unclear, severalstudies have shown that endothelial cell dysfunction plays an important role in ...
María Paula Martínez Linares, Juan Guillermo Lozano de Castro   +1 more
doaj  

Treatment design to prevent hepatic triglyceride accumulation.

, 2013
A computational analysis was performed to explore the possibility to prevent hepatic triglyceride accumulation upon T0901317 treatment by targeting the triglyceride catabolism capacity ().
Maaike H. Oosterveer (262779), Christian A. Tiemann (440657), Natal A. W. van Riel (175595), Joep Vanlier (440658), Albert K. Groen (128588), Peter A. J. Hilbers (175592)   +5 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Detection Of Triglyceride Based On Microwave Dielectric Properties Of Triglyceride Enzymatic Reaction [PDF]

, 2010
Triglyceride is identified to have an important function in dairy products since it can cause milk rancidity and affect cheese flavor. In this study, the detection of triglyceride was done through the measurement of dielectric properties of ...
Hamid, Hasnidar
core   +1 more source

Pemulihan Kadar Glikogen Serta Peningkatan Konsumsi Glukosa dan Trigliserida Saat Aktivitas Fisik Pascapemberian Ekstrak Kulit Buah Manggis (GLYCOGEN RECOVERY AND INCREASE CONSUMPTION OF GLUCOSE AND TRIGLYCERIDE DURING PHYSICAL ACTIVITIES AFTER ADMINISTRA

Jurnal Veteriner, 2016
This study was aimed to investigate the effect of mangosteen rind on the glycogen recovery of themuscle and the liver, and the glucose and the triglyceride consumption during physical activities. ARandomized Block Design was applied with four treatments:
I Nyoman Arsana, Ni Ketut Ayu Juliasih
doaj