Results 141 to 150 of about 436,927 (259)

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

The obesity paradox effect of triglyceride-glucose-body mass index (TyG-BMI) on all-cause mortality in patients with malignant tumors: a machine learning-driven cohort study. [PDF]

Transl Cancer Res
Wang M, Li Y, Chen J, Dong W, Wang Y, Bo S, Wu P, Wang Z, Zhong Z, Zhong Y.   +9 more
europepmc   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Correction: Triglyceride-Glucose Index and Mortality Risk in the General Population: A Systematic Review and Meta-analysis of Prospective Studies. [PDF]

High Blood Press Cardiovasc Prev
D'Elia L, Stranges S, La Fata E, Fortunato F, Palladino R, Rendina D, Galletti F.   +6 more
europepmc   +1 more source

Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling

Biotechnology and Bioengineering, EarlyView.
Accurate biomass measurements, both offline and online, are essential to improve prediction and control in yeast fermentation. This study develops regression‐based predictive models to correlate offline measurements (Dry Cell Weight and OD600 from a spectrophotometer) with online OD860 probe signals to provide accurate real‐time biomass estimations and
Ana G. Del Hierro, José Luis Checa‐Barrera, Juan A. Moreno‐Cid, Eoin Casey   +3 more
wiley   +1 more source

Triglyceride-Glucose Index as a Predictor of Short-Term Outcomes in Acute Ischemic Stroke: A Prospective Observational Study From Bangladesh. [PDF]

Cureus
Huda ME, Amin MAA, Zerin IA, Rahman MA, Shamsuzzaman M, Alam JAJ, Uddin SMS, Atiqur Rahman M, Chowdhury MTI, Mondal MBA.   +9 more
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

APOC3 Promotes DGAT2-Dependent Triglyceride Accumulation in Hepatocytes During Early Metabolic Dysfunction. [PDF]

Biomolecules
Nguyen TN, Kim HJ, Shim HM, Kang J, Ha EY, Cho H, Park JH.   +6 more
europepmc   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Age- and Sex-Specific Distribution of the Triglyceride-Glucose Index in a Large Chinese Population: Cross-Sectional Study. [PDF]

JMIR Diabetes
Du H, Song S, Zhai X, Liu J, Jiang Y, Hu Y, He H, Li D, Zhu H, Chen S, Shan G, Pan H.   +11 more
europepmc   +1 more source