Results 61 to 70 of about 158 (138)

Pharmacokinetics (PK) of Tiragolumab in First‐in‐Human Study in Patients with Mixed Solid Tumors (GO30103)

The Journal of Clinical Pharmacology, Volume 64, Issue 5, Page 544-554, May 2024.
Abstract Tiragolumab is a first‐in‐class, fully human IgG1/kappa anti‐TIGIT monoclonal antibody that blocks the binding of TIGIT to CD155 (the poliovirus receptor). We summarize the pharmacokinetics (PK) data from the phase 1a/1b GO30103 study of Q3W (every 3 weeks) sequential dosing of tiragolumab (2, 8, 30, 100, 400, 600, or 1200 mg) followed by ...
Elena Garralda, Do Youn Oh, Antoine Italiano, Philippe L. Bedard, Jean‐Pierre Delord, Emiliano Calvo, Patricia LoRusso, Zev Wainberg, Andres Cervantes, Alejo Rodriguez‐Vida, Colby S. Shemesh, Rucha Sane, Diana Mendus, Hao Ding, Robert Hendricks, Ray Meng, Byoung Chul Cho, Tae Won Kim, Benjamin Wu   +18 more
wiley   +1 more source

Implementation of the TRIGRS model with reliability analysis for hazard assessment of shallow rainfall-triggered landslides

TecnoLógicas, 2019
Landslides triggered by rainfall infiltration are common in tropical regions. Slope failures represent one of the most common causes of human and economic losses around the world.
Edwin Fabián García-Aristizábal, Edier Vicente Aristizábal Giraldo, Roberto José Marín Sánchez, Juan Carlos Guzmán Martínez   +3 more
doaj   +1 more source

Evaluation of shallow landslide-triggering scenarios through a physically based approach: an example of application in the southern Messina area (northeastern Sicily, Italy) [PDF]

Natural Hazards and Earth System Sciences, 2015
Rainfall-induced shallow landslides are a widespread phenomenon that frequently causes substantial damage to property, as well as numerous casualties. In recent~years a wide range of physically based models have been developed to analyze the triggering ...
L. Schilirò, C. Esposito, G. Scarascia Mugnozza   +2 more
doaj   +1 more source

Does a prior diagnosis of infectious disease confer an increased risk of latent autoimmune diabetes in adults?

Diabetes/Metabolism Research and Reviews, Volume 40, Issue 3, March 2024.
Abstract Aims Infections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA). Materials and methods We used data from a population‐based Swedish case‐control study with incident cases of LADA (n = 597) and matched ...
Jessica Edstorp, Marios Rossides, Emma Ahlqvist, Bahareh Rasouli, Tiinamaija Tuomi, Sofia Carlsson   +5 more
wiley   +1 more source

Exploring the effect of soil zoning in the TRIGRS and Scoops3D integrated model on the stability of rainfall-induced shallow landslides

Geomatics, Natural Hazards & Risk
Nanxi Town, located in Yunyang County within the Three Gorges Reservoir Area of Chongqing, faces high rainfall and frequent geological disasters, causing significant casualties and property damage.
Siyu Liang, Li Li, Yue Qiang, Xinlong Xu, Wenjun Yang, Tao Chen, Chen Cheng, Nanxi Chen   +7 more
doaj   +1 more source

Evaluación del riesgo de deslizamientos superficiales para proyectos de infraestructura: caso de análisis en vereda El Cabuyal

Ingeniería y Ciencia, 2018
Este artículo presenta un análisis y evaluación cuantitativa de la amenaza, la vulnerabilidad y el riesgo asociados a deslizamientos superficiales en una subcuenca del Valle de Aburrá (Colombia).
Roberto J. Marín, Juan Carlos Guzmán-Martínez, Hernán Eduardo Martínez Carvajal, Edwin F. García-Aristizábal, Juan Diego Cadavid-Arango, Paulina Agudelo-Vallejo   +5 more
doaj   +1 more source

Using an integrated method to estimate watershed sediment yield during heavy rain period: a case study in Hualien County, Taiwan [PDF]

Natural Hazards and Earth System Sciences, 2012
A comprehensive approach estimating sediment yield from a watershed is needed to develop better measures for mitigating sediment disasters and assessing downstream impacts.
S. M. Hsu, H. Y. Wen, N. C. Chen, S. Y. Hsu, S. Y. Chi   +4 more
doaj   +1 more source

Advancing rainfall-induced landslide hazard mapping: comparative study of semi-quantitative, statistical, hybrid, and deterministic models

Geomatics, Natural Hazards & Risk
Landslide hazard mapping is crucial for risk assessment, land-use planning, and disaster mitigation, especially in regions prone to rainfall-induced slope failures. This study compares five landslide hazard mapping approaches: Analytic Hierarchy Process (
Terdkiad Nontapot, Kuo Chieh Chao
doaj   +1 more source

Constructing Rainfall Threshold for Debris Flows of a Defined Hazardous Magnitude

Remote Sensing
Debris flow can cause damage only when its discharge exceeds the drainage capacity of the prevention engineering. At present, most rainfall thresholds for debris flows mainly focus on the initiation of debris flow and do not adequately consider the ...
Yajun Li, Mengyu Wang, Fukang Ma, Jun Zhang, Guowei Li, Xingmin Meng, Guan Chen, Dongxia Yue, Fuyun Guo, Yan Zhao   +9 more
doaj   +1 more source

Failure of TRIGR Study Opens Door to Alternative Explanation of T1DM Etiopathology

Journal of Diabetes & Metabolism, 2018
The first 2018 JAMA issue reported results of the TRIGR study. The Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR) study was a 78 center, 15 country study initiated to see if weaning to a hydrolyzed infant formula decreased type 1 diabetes in at-risk children.
openaire   +1 more source