Results 51 to 60 of about 4,789,934 (292)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Optimal Skip Entry Trajectory for Lunar Return Vehicle with Trim‐Flaps [PDF]
Mathematical Problems in Engineering, 2017 A medium lift‐to‐drag ratio lunar return vehicle with trim‐flaps is presented in this paper. The trajectory optimization design under heat‐rate constrain for skip entry lunar return vehicle is analyzed. The optimization problem with a first‐order state constraint is introduced.
Yin Wang, Keming Yao
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Research on Cutting Path Optimization of Trimming Process
Journal of Physics: Conference Series, 2020 Abstract For a stamped part, excess material on the edge need to be cut to get the final part. To explore the impact of different laser-cutting paths on the accuracy of part formed by multi-point forming with blank-holder, three different cutting paths are designed in this paper, and the process of laser-cutting is simulated by finite ...
Yingnan Liu +3 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Advances in Mechanical Engineering, 2020 Herein, the design optimization of multi-objective controllers for the lateral–directional motion using proportional–integral–derivative controllers for a twin-engine, propeller-driven airplane is presented.
Mohsen Rostami +2 more
doaj +1 more source
Aerospace, 2023 Most existing aerodynamic shape optimization (ASO) studies do not take the balanced pitching moment into account and thus the optimized configuration has to be trimmed to ensure zero pitching moment, which causes additional drag and reduces the benefit ...
Kai Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Innovating Aircraft Repair Processes: The Role of Digitalization in Sustainability
Advanced Engineering Materials, EarlyView.This research explores how digitalization—by storing detailed non‐destructive testing data in structured DICONDE databases and creating a standard data model of the component—innovates aviation maintenance and repair processes. Coupled with a developed state‐based simulation model, it enables data‐driven, sustainable repair strategies that reduce waste,
Johanna Aigner +3 more
wiley +1 more source