Results 231 to 240 of about 12,013 (243)

Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways

Toxicology Mechanisms and Methods, 2023
Tramadol (TRA) causes neurotoxicity whereas trimetazidine (TMZ) is neuroprotective. The potential involvement of the PI3K/Akt/mTOR signaling pathway in the neuroprotection of TMZ against TRA-induced neurotoxicity was evaluated.
Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, Fereshteh Taheri, A. Hayes, M. Gholami, Ahmad Alavi, M. Motaghinejad   +7 more
semanticscholar   +1 more source

Gentiopicroside enhances the protective effect of trimetazidine against myocardial ischemia‐reperfusion injury via the AMPK/NLRP3 inflammasome signaling

Journal of biochemical and molecular toxicology, 2023
Myocardial ischemia‐reperfusion injury (MI/R) leads to the inevitable clinical consequences of myocardial infarction and subsequent heart failure. Trimetazidine (TMZ), an anti‐ischemic agent, exerts protective potential in MI/R but had limited efficacy ...
Yu Wang, Yao Sheng, Ningning Ji, Hui Zhang   +3 more
semanticscholar   +1 more source

The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway

Journal of biochemical and molecular toxicology, 2022
Late diagnosis and treatment of ovarian ischemia can lead to worsening of ischemia, irreversible damage to ovarian functions and infertility. In this process, there is no approved medical treatment that can reduce the negative effects of ischemia and ...
Aykut Ozturk, A. Topçu, Esra Deniz, Seda Duman Ozturk, M. Arpa, Eda Kutlu Yilmaz   +5 more
semanticscholar   +1 more source

Beneficial effect of trimetazidine on folic acid‐induced acute kidney injury in mice: Role of HIF‐1α/HO‐1

Journal of biochemical and molecular toxicology, 2022
Acute kidney injury (AKI) is a complex syndrome associated with a decrease in renal function and a significant impact on patient outcomes. Injection of folic acid (FA) in mice is used for studying the pathogenesis of AKI.
R. S. Abdelrahman, R. Abdelsalam, M. Zaghloul   +2 more
semanticscholar   +1 more source

Doping control analysis of trimetazidine in dried blood spot.

Drug Testing and Analysis, 2022
Dried blood spot (DBS) analysis has been an inherent part of sports drug testing through the technological advancements of the past decade. Trimetazidine, a non-threshold banned substance, is excreted into urine after a dose of the permitted drug ...
M. Okano, Asami Miyamoto, Masanori Ota, Shinji Kageyama, Mitsuhiko Sato   +4 more
semanticscholar   +1 more source

Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
M. Farzaei, Fatemeh Ramezani-Aliakbari, Maryam Ramezani-Aliakbari, M. Zarei, A. Komaki, S. Shahidi, A. Sarihi, I. Salehi   +7 more
semanticscholar   +1 more source

Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NFκB and klotho protein expression.

Chemico-Biological Interactions, 2023
A. Hammad, M. Sayed-Ahmed, S. M. A. Abdel Hafez, Ahmed R. N. Ibrahim, M. Khalifa, M. El-Daly   +5 more
semanticscholar   +1 more source

Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury

Inflammation Research, 2022
Xudong Chen, Shuang Lin, S. Dai, Jibo Han, P. Shan, Weiqi Wang, Zhouqing Huang, Bozhi Ye, Weijian Huang   +8 more
semanticscholar   +1 more source

Trimetazidine attenuates cyclophosphamide-induced cystitis by inhibiting TLR4-mediated NFκB signaling in mice.

Life Science, 2022
Seçkin Engin, Elif Nur Barut, Yeşim Kaya Yaşar, A. Soysal, Tuğba Arıcı, G. Kerimoğlu, M. Kadioglu, S. Sezen   +7 more
semanticscholar   +1 more source

Assessment of Gas Chromatography Methodology Approach for the Trace Evaluation of Carcinogenic Impurity, Methyl Chloride, in Trimetazidine Dihydrochloride.

Annales Pharmaceutiques Françaises, 2022
Rajesh Varma Bhupatiraju, Sreenivasa Rao Battula, K. N. Rao, M. V. Reddy   +3 more
semanticscholar   +1 more source