Targeting non-structural proteins of Hepatitis C virus for predicting repurposed drugs using QSAR and machine learning approaches [PDF]
Computational and Structural Biotechnology Journal, 2022 Hepatitis C virus (HCV) infection causes viral hepatitis leading to hepatocellular carcinoma. Despite the clinical use of direct-acting antivirals (DAAs) still there is treatment failure in 5–10% cases.
Sakshi Kamboj +4 more
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Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level [PDF]
Frontiers in Neuroscience, 2021 BackgroundThe sympathetic arterial baroreflex is a closed-loop feedback system for stabilizing arterial pressure (AP). Identification of unique functions of the closed system in humans is a challenge. Here we propose an analytic and integrative framework
Fumiyasu Yamasaki +3 more
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Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundBlack women have one of the highest prevalence rates of hypertension and obesity in the United States. We previously reported that sympathetic activation induced by obesity is a significant contributor to hypertension in white patients.
Alejandro Marinos +9 more
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Trimethaphan-induced hypotension: effect on renal function [PDF]
Canadian Anaesthetists’ Society Journal, 1982 This study was designed to evaluate the effects of trimethaphan-induced hypotension on renal function in healthy young patients undergoing maxillofacial surgery. Anaesthesia was induced with thiopentone and was maintained with halothane 1.5-2.0 per cent in oxygen.
R, Behnia +3 more
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The cerebral response to sodium nitroprusside and trimethaphan controlled hypotension [PDF]
Canadian Anaesthetists’ Society Journal, 1975 Cette etude avait pour but d’etablir la marge de securite associee a l’emploi d’hypotension controllee en neuro-chirurgie, hypotension produite soit avec du Trimethaphan ou du Nitro-prussiate. Ces agents par leur action sur la resistance vasculaire permettent de diminuer la pression de perfusion cerebrale (C.P.P.) tout en maintenant le flot sanguin ...
W W, Stoyka, H, Schutz
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The impact of ageing and sex on sympathetic neurocirculatory regulation. [PDF]
Semin Cell Dev Biol, 2021 Klassen SA, Joyner MJ, Baker SE.
europepmc +1 more source
Revealing the dynamic landscape of drug-drug interactions through network analysis. [PDF]
Front Pharmacol, 2023 Jeong E +5 more
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The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. [PDF]
JCI Insight, 2021 Willmes DM +25 more
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Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea. [PDF]
Int J Mol Sci, 2023 Bock JM +3 more
europepmc +1 more source
Skin sympathetic nerve activity and nocturnal blood pressure nondipping in patients with postural orthostatic tachycardia syndrome. [PDF]
J Hypertens, 2023 Liu X +10 more
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