Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level [PDF]
Frontiers in Neuroscience, 2021 BackgroundThe sympathetic arterial baroreflex is a closed-loop feedback system for stabilizing arterial pressure (AP). Identification of unique functions of the closed system in humans is a challenge. Here we propose an analytic and integrative framework
Fumiyasu Yamasaki +3 more
doaj +2 more sources
Targeting non-structural proteins of Hepatitis C virus for predicting repurposed drugs using QSAR and machine learning approaches [PDF]
Computational and Structural Biotechnology Journal, 2022 Hepatitis C virus (HCV) infection causes viral hepatitis leading to hepatocellular carcinoma. Despite the clinical use of direct-acting antivirals (DAAs) still there is treatment failure in 5–10% cases.
Sakshi Kamboj +4 more
doaj +2 more sources
Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundBlack women have one of the highest prevalence rates of hypertension and obesity in the United States. We previously reported that sympathetic activation induced by obesity is a significant contributor to hypertension in white patients.
Alejandro Marinos +9 more
doaj +2 more sources
The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. [PDF]
JCI Insight, 2021 Reduced expression of the plasma membrane citrate transporter INDY (acronym I'm Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restriction ...
Willmes DM +25 more
europepmc +4 more sources
Trimethaphan-induced hypotension: effect on renal function [PDF]
Canadian Anaesthetists' Society Journal, 1982 This study was designed to evaluate the effects of trimethaphan-induced hypotension on renal function in healthy young patients undergoing maxillofacial surgery. Anaesthesia was induced with thiopentone and was maintained with halothane 1.5-2.0 per cent in oxygen.
R, Behnia +3 more
exaly +3 more sources
Micro-RNA family that modulates fibrosis and uses thereof [PDF]
, 2017 The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core +1 more source
Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]
, 2015 A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core +1 more source
Spontanous periodic breathing is associated with sympathetic hyperreactivity and baroreceptor dysfunction in hypertension [PDF]
, 2010 OBJECTIVES: Intermittent periods of hypoxemia such as during periodic breathing are associated with hypertension and increased sympathetic activity. In patients with sleep apnea syndrome, hypertension is common.
Binggeli, C +6 more
core +1 more source
Micro-RNAS that control myosin expression and myofiber identity [PDF]
, 2015 The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber
Olson, Eric N., van Rooij, Eva
core +1 more source
Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes [PDF]
, 2014 Mice overexpressing human alpha-synuclein in oligodendrocytes (MBP1-alpha-syn) recapitulate some key functional and neuropathological features of multiple system atrophy (MSA).
da Costa-Goncalves, A.C. +9 more
core +1 more source