Results 61 to 70 of about 409 (103)

Cerebral tissue lactate in trimethaphan-induced hypotension

The American Journal of Surgery, 1971
Abstract Ischemic effects of profound sustained hypotension upon the brain utilizing trimethaphan have been investigated because of frequent clinical utilization by surgeons. In ten dogs hypotension (30 to 40 mm Hg MAP) was sustained for one hour. Cerebral tissue lactate accumulation was assessed at five, thirty, and sixty minutes.
G E, Locke, D, Yashon, W E, Hunt
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Effect of Trimethaphan on Intraocular Pressure in Electroconvulsive Therapy

Archives of Ophthalmology, 1963
According to Hibbeler, 4 patients suffering from glaucoma rather frequently have mental disturbances, and when electroconvulsive therapy becomes necessary the problem arises of how such treatment will affect the glaucoma. A report of ten patients suffering from glaucoma treated with electroconvulsive therapy at different clinics in the United States ...
J O, OTTOSSON, I, RENDAHL
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Mixtures of Sodium Nitroprusside and Trimethaphan for Induction of Hypotension

Anesthesia & Analgesia, 1991
A mixture of sodium nitroprusside (SNP) and trimethaphan, empirical 1:10 weight ratio, has been advocated to decrease untoward side effects of SNP when used to induce hypotension during anesthesia and operation. The purpose of this study was to investigate the effects of various ratios of mixtures of SNP and trimethaphan on heart rate (HR), renal ...
K, Nakazawa, C, Taneyama, K T, Benson, G K, Unruh, H, Goto   +4 more
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Preservation of Platelet Function During Trimethaphan Infusion

Anesthesiology, 1990
The effect of trimethaphan (Arfonad) infusion on platelet function was prospectively evaluated in 38 (n = 38) patients (28 patients receiving trimethaphan, ten control patients) undergoing elective cardiac surgery. Any patient with a positive history for the ingestion of medication known to interfere with platelet function was excluded from the study ...
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The effect of trimethaphan camphorsulfonate on the human digital circulation

Clinical Pharmacology & Therapeutics, 1968
The effect of l‐norepinephrine (NE) infusion on the digital circulation was studied in four groups of patients: normotensive subjects prepared by indirect heating supplemented by (a) intravenous 2,6‐dimethyl,‐1‐diethyl piperidinium bromide (SC‐1950) or (b) by intravenous trimethaphan camphorsulfonate (TMCS); and hypertensive subjects prepared in the ...
M, Mendlowitz, N E, Naftchi, R L, Wolf, S E, Gitlow   +3 more
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Blockade of Smoking Satisfaction Using the Peripheral Nicotinic Antagonist Trimethaphan

Pharmacology Biochemistry and Behavior, 1999
The present study was conducted to investigate the role of peripheral nicotinic receptors in mediating the rewarding effects of cigarette smoking. Twelve cigarette smokers rated cigarettes after intravenous infusion of the short-acting peripheral nicotinic receptor antagonist trimethaphan and after placebo (saline) infusions.
J E, Rose, E C, Westman, F M, Behm, M P, Johnson, J S, Goldberg   +4 more
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A COMPARISON OF THE CARDIOVASCULAR EFFECTS OF SODIUM NITROPRUSSIDE AND TRIMETHAPHAN

Survey of Anesthesiology, 1977
In dogs anesthetized with pentobarbital-chloralose, cardiac output and blood flows of four regional vascular beds (superior mesenteric, left renal, left circumflex coronary and left femoral) were continuously monitered with electromagnetic flowmeters. Arterial blood pressure and heart rate were also measured.
H H, Wang, L M, Liu, R L, Katz
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Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1993
To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal surgery, EBF was measured using the heat clearance method in 30 patients who underwent postero-lateral interbody fusion under isoflurane anaesthesia. An initial dose of 0.1 microgram.kg-1.min-1 of PGE1 (15 patients), or
K, Abe, M, Kakiuchi, Y, Shimada
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Trimethaphan as a glutamate inhibitor at the Crayfish neuromuscular junction

Brain Research, 1983
At the crayfish neuromuscular junction trimethaphan reduced the amplitude of both the glutamate-induced synaptic current and the excitatory junctional current in a dose-dependent manner at concentrations greater than 5 microM. These effects were dependent on membrane potential.
H, Shinozaki, M, Ishida
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Trimethaphan camsylate (Arfonad) and human plasma cholinesterase.

Research communications in chemical pathology and pharmacology, 1979
These results for the first time document that the brief duration of action of the ganglionic blocker, Arfonad (trimethaphan camsylate), is not due to inactivation by plasma cholinesterase. Inhibition of the enzyme in vitro by Arfonad was not altered by prior incubation of the drug in plasma at 37 degrees C for up to 16 hours nor by treatment with ...
A H, Anton, S, Czinn, J, Jazwa, L, Tam, L, Amaranath   +4 more
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