Results 21 to 30 of about 5,440 (162)

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability [PDF]

, 2012
As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, independent of cross-link density and
Griffith, Linda G., Hammond, Paula T., Morey, Shannon M., Oelker, Abigail M.   +3 more
core   +1 more source

Results of GC–MS Analyses of 40 Extracts of Diabetes Devices

Contact Dermatitis, EarlyView.
Forty acetone extracts of 27 diabetes devices were investigated by gas chromatography–mass spectrometry. Two hundred eighty four individual chemicals were identified. All 40 extracts contained one or more chemicals that were previously identified as allergens in diabetes devices causing allergic Contact Dermatitis.
Emma M. van Oers, Anton C. de Groot, Patrick Verolme, Norbertus A. Ipenburg, Thomas Rustemeyer   +4 more
wiley   +1 more source

High Yielding Lithiation of Azobenzenes by Tin-Lithium Exchange [PDF]

, 2015
The lithiation of halogenated azobenzenes by a halogen-lithium exchange commonly leads to a substantial degradation of the azo-group to give hydrazine derivatives besides the desired aryl-lithium species. Yields for quenching reactions with electrophiles
A Gould, Colin, Gates, Paul J, Lipfert, Matthias, Springer, Jan-Ole, Staubitz, Anne, Strueben, Jan, Sönnichsen, Frank   +6 more
core   +2 more sources

Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model. [PDF]

, 2013
The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di-
Garg, Neil K, Goetz, Adam E
core  

Lithium, sodium, and potassium magnesiate chemistry : a structural overview [PDF]

, 2016
Until recently, deprotonative metalation reactions have been performed using organometallic compounds that contain only a single metal (eg, organolithium reagents).
Martínez-Martínez, A. J., O'Hara, C. T.   +1 more
core   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Polypeptide-grafted macroporous polyHIPE by surface-initiated N-Carboxyanhydride (NCA) polymerization as a platform for bioconjugation [PDF]

, 2012
A new class of functional macroporous monoliths from polymerized high internal phase emulsion (polyHIPE) with tunable surface functional groups was developed by direct polypeptide surface grafting.
Andreas Heise, Audouin F., Audouin F., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbey R., Blout E. R., Borase T., Brendan O’Connor, Brunauer S., Busby W., Cameron N. R., Cameron N. R., Carlsen A., Carnachan R. J., Cormack B. P., Cummins D., Cummins D., Deleuze H., Deming T. J., Dimitrov I., Engler A. C., Fabrice Audouin, Fernandez-Trillo F., Gibson M. I., Gokmen M. T., Habraken G. J. M., Habraken G. J. M., Habraken G. J. M., Hadjichristidis N., Hainey P., Heim R., Huang J., Jerabek K., Jin Huang, Kimmins S. D., Klok H.-A., Kovacic S., Krajnc P., Krajnc P., Kricheldorf H. R., Leber N., Livshin S., Lovelady E., Lu H., Lucchesi C., Mary Fox, Moglia R. S., Moine L., Orndorff W. R., Paul Clarke, Pierre S. J., Pulko I., Ruth Larragy, Schlaad H., Schwab M. G., Su F., Subramanian G., Sun J., Tang H., Tsien R., Tunc Y., Youssef C.   +66 more
core   +1 more source

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, Volume 25, Issue 12, December 2025.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

Catalytic Addition of Simple Alkenes to Carbonyl Compounds by Use of Group 10 Metals [PDF]

, 2009
Recent advances using nickel complexes in the activation of unactivated monosubstituted olefins for catalytic intermolecular carbon-carbon bond-forming reactions with carbonyl compounds, such as simple aldehydes, isocyanates, and conjugated aldehydes and
Chan, Chun-Wa, Ho, Chun-Yu, Jamison, Timothy F., Schleicher, Kristin D.   +3 more
core   +1 more source