Results 11 to 20 of about 19,593 (221)

Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer. [PDF]

Trends Cancer, 2018
Many neurodegenerative diseases are caused by unstable trinucleotide repeat (TNR) expansions located in disease-associated genes. siRNAs based on CAG repeat expansions effectively kill cancer cell lines in vitro through RNAi. They also cause significant reduction in tumor growth in a human ovarian cancer mouse model with no toxicity to the treated mice.
Murmann AE, Yu J, Opal P, Peter ME.
europepmc   +6 more sources

DNA base excision repair: a mechanism of trinucleotide repeat expansion. [PDF]

Trends Biochem Sci, 2012
The expansion of trinucleotide repeat (TNR) sequences in human DNA is considered to be a key factor in the pathogenesis of more than 40 neurodegenerative diseases. TNR expansion occurs during DNA replication and also, as suggested by recent studies, during the repair of DNA lesions produced by oxidative stress.
Liu Y, Wilson SH.
europepmc   +6 more sources

DNA methylation and trinucleotide repeat expansion diseases [PDF]

, 2012
Copyright @ 2012 InTechThis article has been made available through the Brunel Open Access Publishing Fund.This article is made available through the Brunel Open Access Publishing ...
Pook, M
core   +6 more sources

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair. [PDF]

Nucleic Acids Res, 2015
Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases.
Beaver JM, Lai Y, Xu M, Casin AH, Laverde EE, Liu Y.   +5 more
europepmc   +2 more sources

Beyond Trinucleotide Repeat Expansion in Fragile X Syndrome: Rare Coding and Noncoding Variants in FMR1 and Associated Phenotypes. [PDF]

Genes (Basel), 2021
Tekendo-Ngongang C, Grochowsky A, Solomon BD, Yano ST.   +3 more
europepmc   +3 more sources

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy. [PDF]

Invest Ophthalmol Vis Sci, 2019
Okumura N, Hayashi R, Nakano M, Yoshii K, Tashiro K, Sato T, Blake DJ, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Nakahara M, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N.   +18 more
europepmc   +3 more sources

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells. [PDF]

Nucleic Acids Res, 2018
Dastidar S, Ardui S, Singh K, Majumdar D, Nair N, Fu Y, Reyon D, Samara E, Gerli MFM, Klein AF, De Schrijver W, Tipanee J, Seneca S, Tulalamba W, Wang H, Chai YC, In't Veld P, Furling D, Tedesco FS, Vermeesch JR, Joung JK, Chuah MK, VandenDriessche T.   +22 more
europepmc   +3 more sources

Trinucleotide repeat expansion and RNA dysregulation in fragile X syndrome: emerging therapeutic approaches. [PDF]

RNA
Jung S, Richter JD.
europepmc   +3 more sources

Increased Risk of Glaucoma in Fuchs Endothelial Corneal Dystrophy Is Independent of TCF4 Trinucleotide Repeat Expansion. [PDF]

Cornea
Xing C, Schultis S, Bondar V, Gong X, Whitson JT, Mootha VV.   +5 more
europepmc   +2 more sources

Trinucleotide repeat expansion length as a predictor of the clinical progression of Fuchs' Endothelial Corneal Dystrophy. [PDF]

PLoS One, 2019
Soh YQ, Peh Swee Lim G, Htoon HM, Gong X, Mootha VV, Vithana EN, Kocaba V, Mehta JS.   +7 more
europepmc   +3 more sources