Results 31 to 40 of about 19,369 (257)
Materials & Design, 2023 This study proposes a kinetic Monte Carlo (KMC) model for the sintering of two-phase composites using nickel oxide-yttria stabilized zirconia (NiO-YSZ) as a case study. An artificial neural network (ANN) assisted method is used to calibrate the KMC model
Shihao Zhou +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Қарағанды университетінің хабаршысы. Физика сериясыA thorough investigation was carried out on nickel-based anode composites with scandia-stabilized zirconia (Ni/ScSZ), fabricated using ceramic processing techniques from powders with varying particle sizes.
S. Adaikhan +8 more
doaj +1 more source
Microstructure and mechanical properties of Fe40Cr25Ni25Al5Ti5 medium entropy alloy
Cailiao gongcheng, 2023 Fe40Cr25Ni25Al5Ti5 (atom fraction/%) medium entropy alloys (MEAs) were prepared by a vacuum arc-melting furnace with a water-cooled copper mold, and the microstructure, mechanical properties and strengthening deformation mechanism of the alloy in solid ...
HU Zhaohui +6 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Coercivity enhancement of (Nd,Ce)-Fe-B sintered magnets by doping Nd-Fe additives
AIP Advances, 2017 The effect of Nd-Fe additives on magnetic properties and microstructure in (Nd,Ce)-Fe-B sintered magnet has been investigated. By doping 3wt% Nd-Fe additives, the coercivity of the magnet increases from 10.56kOe to 12.69kOe with slight remanence decrease.
K. Chen +7 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source