Results 61 to 70 of about 18,192 (253)

Neutron research of the structure transition micelle to crystallites in liquid system D2O-tetradecyltrimethilammonium bromide-NaBr [PDF]

Ядерна фізика та енергетика, 2010
Structure transition in triple liquid system D2O-tetradecyltrimethilammonium bromide-NaBr was studied by means of small-angle neutron scattering in a wide range of temperature, pressure and salt concentrations.
L. A. Bulavin, O. I. Ivankov, V. M. Sysoev   +2 more
doaj  

A thermodynamic description of metastable c-TiAlZrN coatings with triple spinodally decomposed domains [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy, 2017
A critical thermodynamic assessment of the metastable c-TiAlZrN coatings, which are reported to spinodally decompose into triple domains, i.e., c-TiN, c-AlN, and c-ZrN, was performed via the CALculation of PHAse Diagram (CALPHAD) technique based
Zhou J., Zhang L., Chen L., Du Y., Liu Z.K.   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Initiation mechanism of micro-defects in polycrystalline iron under high-temperature stress coupling effect

Materials & Design
To investigate the failure mechanism of high-temperature fracture in polycrystalline iron, this study conducted in-situ observation experiments to study the dynamic damage evolution process of iron under tensile loading at high temperatures.
Qian Wu, Anfeng Yu, Yuchen Wang, Yi Qin, Zetian Kang, Huan Liu   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Kinetic description of intense beam propagation through a periodic focusing field for uniform phase-space density

Physical Review Special Topics. Accelerators and Beams, 2002
The Vlasov-Maxwell equations are used to investigate the nonlinear evolution of an intense sheet beam with distribution function f_{b}\(x,x^{′},s\) propagating through a periodic focusing lattice κ_{x}\(s+S\)=κ_{x}\(s\), where S=const is the lattice ...
Ronald C. Davidson, Hong Qin, Stephan I. Tzenov, Edward A. Startsev   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Synergistic creep strengthening by multi-component L12 and MC carbides in an additively manufactured hierarchical heterostructure

Materials Research Letters
An additively manufactured hierarchical triple-phase heterostructure, comprising a face-centred cubic (FCC) matrix, multi-component L12 precipitates, and nanoscale MC carbides, is engineered in a Ni-rich multi-component alloy through the composition ...
Zhicheng Wei, Zhenfei Jiang, Shiwei Wu, Lei Fan, Shoufeng Yang, Peter K. Liaw, Tao Yang   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source