Results 111 to 120 of about 6,326,042 (362)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

D’une échelle à l’autre : quartiers en ville, quartiers en marge.

open access: yesEspacesTemps.net, 2007
D’aucuns avaient annoncé la fin des quartiers et, par là, la fin des villes. Dans la triple perspective de l’explosion de la mobilité quotidienne, de l’ample mouvement de desserrement urbain et de la remise en cause d’une planification rigide fondée sur ...
Miguel Padeiro
doaj  

L’inspection générale de l’éducation nationale

open access: yesRevue Internationale d’Éducation de Sèvres, 1995
Historiquement liée à la centralisation de l’administration française, l’inspection générale a vu son rôle s’étendre et se diversifier au cours des décennies mais son statut et ses missions n’ont été redéfinies que récemment.
Alain Attali
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

The desing of Triple Function Substations in combination with RELaTED technologies

open access: green, 2021
Matteo Caramaschi   +10 more
openalex   +1 more source

Diplomacia de la Triple Frontera. La participación argentina

open access: yesRFCE, 2018
La problemática de la Triple Frontera entre Argentina, Brasil y Paraguay es, por definición, compleja. Uno de los problemas de este espacio transfronterizo ha sido su gobernanza. Si bien se estableció un sistema institucional y diplomático de cooperación entre actores estatales para gestionar la región, los intereses de cada uno de estos actores ...
openaire   +5 more sources

Diophantus' 20th Problem and Fermat's Last Theorem for n=4: Formalization of Fermat's Proofs in the Coq Proof Assistant

open access: yes, 2005
We present the proof of Diophantus' 20th problem (book VI of Diophantus' Arithmetica), which consists in wondering if there exist right triangles whose sides may be measured as integers and whose surface may be a square.
Delahaye, David, Mayero, Micaela
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

La Suisse urbaine à l'orée du 3e millénaire : risques et défis d'un changement non programmé [PDF]

open access: yesGeographica Helvetica
Introduisant, à titre d'éditeur invité, les autres travaux de ce numéro consacré à une présentation de certains aspects des connaissances et pratiques de la géographie humaine en Suisse romande à travers une réflexion prospective sur les devenirs de la ...
J. Racine
doaj   +1 more source

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