Results 141 to 150 of about 6,326,042 (362)

Changements de pratique en médecine de famille : conséquences de la féminisation et des différences générationnelles

Atlantis, 2015
Résumé À partir de 48 entrevues menées auprès de médecins de famille du Nouveau-Brunswick, cet article expose le triple phénomène qui frappe cette profession : la féminisation de la médecine, le désir des jeunes médecins de famille d’avoir un équilibre ...
Pierrette Fortin, Marie-Pier Cloutier, Julie Easley, Ryan Hamilton   +3 more
doaj  

Lower bounds for ranks of Mumford-Tate groups

, 2013
Let A be a complex abelian variety and G its Mumford--Tate group. Supposing that the simple abelian subvarieties of A are pairwise non-isogenous, we find a lower bound for the rank of G, which is a little less than log_2 dim A.
Orr, Martin
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Pourquoi la réouverture des mines en France constitue un triple défi

, 2023
Sébastien Chailleux, Sylvain Le Berre, Y. Gunzburger   +2 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Poésie camerounaise et le syndrome minoritaire [PDF]

Annales du Patrimoine
La réglementation de l’occupation de l’Afrique codifiée pendant la seconde conférence de Berlin est à l’origine de l’éparpillement des ethnies et de la recomposition identitaire des Etats postcoloniaux.
Fernando Ligue Engamba
doaj  

Journaliers, au confluent de l’intergénéricité, de l’interartialité et de l’interculturalité, vu de l’œil mystique Eberhardtien

Altralang Journal
: Our present article is part of the aspect of the hybridity of genres, arts and cultures or what we call intergenericity, interartiality and interculturality, because working on the writing of Isabelle EBERHARDT seems far from being completely univocal.
Malika GUEBAILIA, Sihem GUETTAFI
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Los caminos de un triple desafío

, 1970
"Lara, Fernando, 1947-" tambi?n ha firmado sus art?culos como "Valle, Ram?n"
openaire   +1 more source