Results 71 to 80 of about 6,326,042 (362)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Efficience des pratiques responsables des entreprises cotées en bourse de Casablanca. Une analyse par la méthode DEA

open access: yesRevue des Sciences Humaines et Sociales de l’Académie du Royaume du Maroc
Cet article a pour objectif l’évaluation de l'efficience des pratiques responsables, en tenant compte des trois dimensions du Triple Bottom Line (TBL) : économique, sociale et environnementale.
Otmane OUDRA, Khalid OULAD SEGHIR
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Sur la durée de présence des engrais phosphatés dans l'eau et leur action sur le milieu

open access: yesKnowledge and Management of Aquatic Ecosystems, 1972
Les essais ont été réalisés à la Station piscicole de BOUAKE (Côte d'Ivoire). Aux doses de 20 et 40 kg/ha de superphosphate triple à 45 % de P2 05 dans des étangs non empoissonnés, les phosphates demeurent respectivement 8 et 15 jours dissous dans l'eau ;
MOREAU J., CAKPO T.
doaj   +1 more source

L’activité en classe de l’enseignant d’EPS et le caractère « situé » des connaissances dans l’action : contribution d’un programme de recherche en anthropologie cognitive

open access: yeseJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2010
Cette conférence vise à présenter un courant de recherche en anthropologie cognitive qui se développe en France depuis les années 1996 (Durand, 2001).
Nathalie Gal-Petitfaux
doaj   +1 more source

Small sets of complementary observables

open access: yes, 2016
Two observables are called complementary if preparing a physical object in an eigenstate of one of them yields a completely random result in a measurement of the other. We investigate small sets of complementary observables that cannot be extended by yet
Grassl, M.   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Histoire et mémoire des aménagements forestiers

open access: yesSciences, Eaux & Territoires, 2002
L'histoire des aménagements forestiers est interrogée d'un triple point de vue. 1) Si les forestiers ont une incontestable légitimité en matière d'aménagement, ils n'ont pas toujours été et ils ne sont plus les seuls à traiter de ces questions qui ...
P. ARNOULD
doaj  

Simulation of a particle-laden turbulent channel flow using an improved stochastic Lagrangian model

open access: yes, 2009
The purpose of this paper is to examine the Lagrangian stochastic modeling of the fluid velocity seen by inertial particles in a nonhomogeneous turbulent flow. A new Langevin-type model, compatible with the transport equation of the drift velocity in the
Anne Tanière   +5 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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