Results 81 to 90 of about 1,154,523 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

THE USE OF TRIPLE JUMP TRAINING DRILLS IN REPLICATING MOVEMENT COORDINATION PATTERNS [PDF]

, 2008
The purpose of this study was to investigate how effective triple jump training drills are at replicating the lower extremity coordination patterns utilised during the triple jump.
Wilson, Cassie, Simpson, Scott, Hamill, Joseph   +2 more
core   +1 more source

Jump deformations and triple cohomology

Journal of Algebra, 1987
The author generalizes the setting of algebraic deformation theory using triples, enriched cohomology modules and triple cohomology groups. Some results of Gerstenhaber on cohomology are generalized to this setting. The familiar definition for a one-parameter deformation to be a jump deformation is dualized to the author's context, and a cohomology ...
openaire   +1 more source

An operations research approach to the triple jump

International Journal of Sport Management and Marketing, 2006
There are wide-ranging views among track and field experts regarding the optimal strategy to use in the triple jump. The controversy pertains to the effort which should be expended in each of the hop, step, and jump phases. In this paper, we develop a dynamic programming approach for finding the optimal strategy.
Jack Brimberg, Bill Hurley, Shaul P. Ladany   +2 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of approach run velocity on the optimal performance of the triple jump

Journal of Sport and Health Science, 2015
Purpose: The purpose of this study was to determine the effect of horizontal and vertical velocities at the landing of the last step of approach run on the performance and optimal phase ratio of the triple jump.
Hui Liu, Dewei Mao, Bing Yu
doaj   +1 more source

Development of Triple jump Learning Model Based Audiovisual for Physical Education Students of Sebelas Maret University [PDF]

, 2020
This research aims toThis research aims to make the product of triple jump learning model based on audio visual in learning athletics in  Physical Education of Sebelas Maret University.The method used is Research and Development.
Sugiyanto, Sugiyanto, Liskustyawati, Hanik, Pamungkas, Ketut   +2 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The effect of increasing strength and approach velocity on triple jump performance.

Journal of Biomechanics, 2016
The triple jump is an athletic event comprising three phases in which the optimal phase ratio (the proportion of each phase to the total distance jumped) is unknown.
S. Allen, M. R. Fred Yeadon, M. King
semanticscholar   +1 more source