Results 111 to 120 of about 112,151 (292)

Impact of a three-week full leg cast immobilization on infant crawling kinetics and spatiotemporal parameters.

PLoS ONE
Despite its importance in the development of mobility in infants, there is a general lack of quantified data on infant crawling, and a specific lack of understanding of crawling kinetics, which includes the relative weightbearing and force generation ...
Mark D Geil
doaj   +1 more source

Finite amplitude thermal convection with variable gravity

International Journal of Mathematics and Mathematical Sciences, 2001
Finite amplitude thermal convection is studied in a horizontal layer of infinite Prandtl number fluid with a variable gravity. For the present study, gravity is restricted to vary quadratically with respect to the vertical variable.
D. N. Riahi, Albert T. Hsui
doaj   +1 more source

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells

Molecules, 2015
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to
Alessandra Longo, Mariangela Librizzi, Irina S. Chuckowree, Christine B. Baltus, John Spencer, Claudio Luparello   +5 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure

Nature Communications
Fumarate hydratase (FH), a key node of mitochondrial metabolism, is also a tumour suppressor. Despite its prominent roles in tumourigenesis and inflammation, its regulation remains poorly understood.
Andrew Roe, Catríona M. Dowling, Cian D’Arcy, Daniel Alencar Rodrigues, Yu Wang, Matthew Hiller, Carl Keogh, Kate E. R. Hollinshead, Massimiliano Garre, Brenton Cavanagh, Kieran Wynne, Tianyan Liu, Zhixing Chen, Emma Kerr, Marie McIlroy, Jochen H. M. Prehn, Ingmar Schoen, Tríona Ní Chonghaile   +17 more
doaj   +1 more source

NELFA-mediated pausing restrains YAP transcription and context-dependent outcomes in breast cancer

Frontiers in Oncology
IntroductionThe Hippo pathway effector YAP signaling is frequently dysregulated in cancer, promoting transcriptional programs linked to tumor progression. However, how general transcriptional control mechanisms intersect with YAP activity remains unclear.
Bhavesh S. Vasave, Bhavesh S. Vasave, Bhavesh S. Vasave, Aadya A. Atreya, Aadya A. Atreya, Aadya A. Atreya, Rishabh D. Kulkarni, Rishabh D. Kulkarni, Sanket S. Nagarkar, Sanket S. Nagarkar, Khushi R. Salvi, Khushi R. Salvi, Khushi R. Salvi, C. B. Koppiker, C. B. Koppiker, L. S. Shashidhara, L. S. Shashidhara, L. S. Shashidhara, L. S. Shashidhara, Madhura D. Kulkarni, Madhura D. Kulkarni   +20 more
doaj   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

V892 Tau: A tidally perturbed circumbinary disc in a triple stellar system

Astronomy & Astrophysics
Context. V892 Tau is a young binary star surrounded by a circumbinary disc that shows hints of an interaction with the low-mass nearby star V892 Tau NE. Aims. The goal of this paper is to constrain the orbit of V892 Tau NE and to determine the resulting circumbinary disc dynamics. Methods.
Antoine Alaguero, Nicolás Cuello, François Ménard, Simone Ceppi, Álvaro Ribas, Rebecca Nealon, Miguel Vioque, Andrés Izquierdo, James Miley, Enrique Macías, Daniel J. Price   +10 more
openaire   +5 more sources

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source