Results 231 to 240 of about 112,151 (292)

Development and validation of a highly accurate multigene gene expression biomarker to predict chemotherapy response in primary triple-negative breast cancer. [PDF]

Breast Cancer Res Treat
Amniouel S, Jafri MS.
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Modern Quantum Chemistry Methodology for Predicting ³¹P Nuclear Magnetic Resonance Chemical Shifts. [PDF]

Int J Mol Sci
Rusakova IL, Rusakov YY.
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

CSFPR-RTDETR-CR: A Causal Intervention Enhanced Framework for Infrared UAV Small Target Detection with Feature Debiasing. [PDF]

Sensors (Basel)
Wang H, Sun L.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer. [PDF]

NPJ Breast Cancer
Shi W, Luo Y, Wang Y, Burrows JM, Black D, Civitarese A, Perlaza-Jimenez L, Zhang P, Manning M, Tuano N, Rentería ME, Xiao C, Tey SK, Rosenbluh J, Smith C, Chenevix-Trench G, Beesley J.   +16 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

scCT-DB, an omnibus for cancer patient-derived paired pre- and post-treatment single-cell transcriptomes to reveal drug perturbation and drug resistance mechanisms. [PDF]

Nucleic Acids Res
Ma S, Jiang J, Zhang R, Ren X, Li D, Li X, Mu H, Liu P, Zuo L, Zhao T, Gu A, Li D, Liu Z.   +12 more
europepmc   +1 more source

Direct Generation and Non-Hermitian Regulation of Energy-Time-Polarization-Hyper-Entangled Quadphotons. [PDF]

Sensors (Basel)
Zhuang R, Zhang S, Liu G, Feng Z, Chen Q, Liu S, Zhang Y.   +6 more
europepmc   +1 more source