Results 21 to 30 of about 23,638 (215)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pressure Transient Analysis and Flux Distribution for Multistage Fractured Horizontal Wells in Triple-Porosity Reservoir Media with Consideration of Stress-Sensitivity Effect

Journal of Chemistry, 2015
Triple-porosity model is usually adopted to describe reservoirs with multiscaled pore spaces, including matrix pores, natural fractures, and vugs.
Jingjing Guo, Haitao Wang, Liehui Zhang, Chengyong Li   +3 more
doaj   +1 more source

Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Advanced Science, 2021
Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disease.
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna‐Katharina Müller, Ulrike A. Köhler, Anne‐Laure Bailly, Emmanuelle Josselin, Rémy Castellano, Christelle Cayrou, Emmanuelle Charafe‐Jauffret, Gordon B. Mills, Vincent Géli, Jean‐Paul Borg, Sima Lev, Flavio Maina   +16 more
doaj   +1 more source

Grid Strength Assessment for Inhomogeneous Multi-infeed HVDC Systems via Generalized Short Circuit Ratio

Journal of Modern Power Systems and Clean Energy, 2023
Generalized short circuit ratio (gSCR) for grid strength assessment of multi-infeed high-voltage direct current (MIDC) systems is a rigorous theoretical extension of the traditional SCR, which enables SCR to be extended to MIDC systems.
Guanzhong Wang, Huanhai Xin, Di Wu, Zhiyi Li, Ping Ju   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Solution for Time-Fractional Coupled Burgers Equations by Generalized-Laplace Transform Methods

Fractal and Fractional
In this work, nonlinear time-fractional coupled Burgers equations are solved utilizing a computational method, which is called the double and triple generalized-Laplace transform and decomposition method.
Hassan Eltayeb, Said Mesloub
doaj   +1 more source

Proposal for a cavity-induced measurement of the exchange coupling in quantum dots

Physical Review Research, 2022
In spin qubit arrays the exchange coupling can be harnessed to implement two-qubit gates and to realize intermediate-range qubit connectivity along a spin bus.
Florian Ginzel, Guido Burkard
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source