Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. [PDF]
Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in
Farshid S Garmaroudi +3 more
doaj +1 more source
Renormalized Internally Contracted Multireference Coupled Cluster with Perturbative Triples
60 pages, 5 figures, 6 ...
Robin Feldmann, Markus Reiher
openaire +5 more sources
Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice.
Mirko Messa +10 more
doaj +1 more source
Empirical Study of Simulated Two-planet Microlensing Event [PDF]
We undertake the first study of two-planet microlensing models recovered from simulations of microlensing events generated by realistic multi-planet systems in which 292 planetary events including 16 two-planet events were detected from 6690 simulated ...
Mao, Shude +5 more
core +3 more sources
Wirtinger-Type Inequality and the Stability Analysis of Delayed Lur'e System
This paper proposes a new delay-depended stability criterion for a class of delayed Lur'e systems with sector and slope restricted nonlinear perturbation.
Zixin Liu +3 more
doaj +1 more source
Observational Detection of Higher-Order Secular Perturbations in Tight Hierarchical Triple Stars
In this work, we search for observational evidence of higher-order secular perturbations in three eclipsing binaries. These are slightly eccentric binaries, and they form the inner pairs of tight, compact, hierarchical triple star systems. Simultaneously, we analyze the high-precision satellite (Kepler and TESS) light curves; eclipse timing variations;
Tamás Borkovits, Tibor Mitnyan
openaire +3 more sources
λ-Interval of Triple Positive Solutions for the Perturbed Gelfand Problem [PDF]
We study a two-point Boundary Value Problem depending on two parameters that represents a mathematical model arising from the combustion theory. Applying fixed point theorems for concave operators, we prove uniqueness, existence, upper, and lower bounds of positive solutions.
Kang, Shugui, Lu, Youmin, Feng, Wenying
openaire +1 more source
Double hybrid density-functional theory using the Coulomb-attenuating method [PDF]
A double hybrid approximation using the Coulomb-attenuating method (CAM-DH) is derived within range-separated density-functional perturbation theory, in the spirit of a recent work by Cornaton {\it et al.} [Phys. Rev. A 88, 022516 (2013)].
Cornaton, Yann, Fromager, Emmanuel
core +1 more source
The triple pomeron interaction in the perturbative QCD [PDF]
17 pages, 4 figures ...
openaire +2 more sources
Global and local aspects of spectral actions [PDF]
The principal object in noncommutatve geometry is the spectral triple consisting of an algebra A, a Hilbert space H, and a Dirac operator D. Field theories are incorporated in this approach by the spectral action principle, that sets the field theory ...
Iochum, Bruno +2 more
core +3 more sources

