Results 111 to 120 of about 212,540 (297)

Designing collagens to shed light on the multi-scale structure–function mapping of matrix disorders

Matrix Biology Plus
Collagens are the most abundant structural proteins in the extracellular matrix of animals and play crucial roles in maintaining the structural integrity and mechanical properties of tissues and organs while mediating important biological processes ...
Sonal Gahlawat, Vikas Nanda, David I. Shreiber   +2 more
doaj   +1 more source

Triple helix structures: sequence dependence, flexibility and mismatch effects.

, 1991
International audienceBy means of molecular modelling, electrostatic interactions are shown to play an important role in the sequence-dependent structure of triple helices formed by a homopyrimidine oligonucleotide bound to a homopurine.
Sun, Js, Helene, C., Lavery, R., Montenay-Garestier, T., Mergny, Jl   +4 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Triple sequences and their statistical convergence

, 2006
Pringsheim gave the definition of the convergence for double sequences in 1900. The idea of statistical convergence was first presented by Fast in 1951. In 2003 Tripathy and Mursaleen et.al introduced statistical convergence of double sequences. In this article we introduce the notions of triple sequences and statistically convergent triple sequence ...
FATMA KADRİYE, DÜDEN, ŞAHİNER, Ahmet, GÜRDAL, Mehmet   +2 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

SOME GENERALIZED TRIPLE SEQUENCE SPACES DEFINED BY MODULUS FUNCTION [PDF]

, 2016
In this paper we have introduced some newly defined triple sequence spaces by combining the modulus function and non-negative six dimensional matrix of the form A=(........) and study some of their topological properties. We have also obtained and proved
Debnath, Shyamal, Das, Bimal Chandra
core  

On rough convergence of triple sequence spaces of Bernstein-Stancu operators of fuzzy numbers defined by a metric function

, 2019
We define the concept of rough limit set of a triple sequence space of Bernstein-Stancu polynomials of fuzzy numbers and obtain the relation between the set of rough limit and the extreme limit points of a triple sequence space of Bernstein-Stancu ...
Esi, Ayhan, Bharathi, M. Jeyaram, Velmurugan, S., Subramanian, N.   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

On rough convergence of triple sequence spaces of Bernstein-Stancu operators of fuzzy numbers defined by a metric function

, 2018
We define the concept of rough limit set of a triple sequence space of Bernstein-Stancu polynomials of fuzzy numbers and obtain the relation between the set of rough limit and the extreme limit points of a triple sequence space of Bernstein-Stancu ...
Bharathi, M. Jeyaram, Velmurugan, S., Subramanian, N., Esi, A.   +3 more
core   +1 more source