Results 91 to 100 of about 1,290,443 (295)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

F.V. Yezerskiy Personality’s Influence on the Development of his Scientific Views

Учёт. Анализ. Аудит
The paper explores accounting theories focusing on the influence of Fyodor Ezerskiy’s, one of the most famous Russian accountants, his identity and surroundings.
V. Ya. Sokolov, S. N. Karelskaia, E. I. Zuga   +2 more
doaj   +1 more source

All proper colorings of every colorable BSTS(15) [PDF]

Computer Science Journal of Moldova, 2010
A Steiner System, denoted S(t,k,v), is a vertex set X containing v vertices, and a collection of subsets of X of size k, called blocks, such that every t vertices from X are in exactly one of the blocks. A Steiner Triple System, or STS, is a special case
Jeremy Mathews, Brett Tolbert
doaj  

Nowcasting in Triple-System Estimation

Journal of Official Statistics
Multiple systems estimation uses samples that each cover part of a population to obtain a total population size estimate. Ideally, all available samples are used, but if some samples are available (much) later, one may use only the samples that are available early. Under some regularity conditions, including sample independence, two samples are enough
Daan B. Zult, Peter G. M. van der Heijden, Bart F. M. Bakker   +2 more
openaire   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cluster Origin of Triple Star HD 188753 and its Planet

, 2005
The recent discovery by M. Konacki of a ``hot Jupiter'' in the hierarchical triple star system HD 188753 challenges established theories of giant-planet formation.
de la Fuente Marcos C., Duquennoy A., Eric Pfahl, Mermilliod J.-C., Mugrauer M.   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Transformation rules for decomposing heterogeneous data into triples

Journal of King Saud University: Computer and Information Sciences, 2015
In order to fulfill the vision of a dataspace system, it requires a flexible, powerful and versatile data model that is able to represent a highly heterogeneous mix of data such as databases, web pages, XML, deep web, and files. In literature, the triple
Mrityunjay Singh, S.K. Jain
doaj   +1 more source