Results 171 to 180 of about 97,595 (299)

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions. [PDF]

Antioxidants (Basel)
Tramutola A, Lanzillotta C, Di Domenico F, Barone E, Perluigi M.   +4 more
europepmc   +1 more source

Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia

American Journal of Hematology, Volume 101, Issue 5, Page 1019-1024, May 2026.
ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Melissa A. Fischer, Zhiguo Zhao, Kateryna Fedorov, Ashwin Kishtagari, Sanjay R. Mohan, Gregory D. Ayers, Michael T. Byrne, Michael R. Savona   +11 more
wiley   +1 more source

Age‐related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD‐related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid‐β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology.
Monika Rataj Baniowska, Paige Mumford, Francesca Prestia, Pauline Stephan, Millie Beament, Marie‐Christine Birling, Chiara Lanzillotta, Letizia Ciafardini, Eugenio Barone, Gloria Lau, Claire Chevalier, Chadia Nahy, Nadia Messaddeq, Thais Lestra, Yixing Wu, Valérie Nalesso, Fabio Di Domenico, Frances Wiseman, Yann Herault   +18 more
wiley   +1 more source

Trisomy [PDF]

, 2020
openaire   +1 more source

Cancer Incidence in People With Intellectual Disability and Down Syndrome in Australia: A Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective There is inconsistent data on cancer risk in people with intellectual disability. Our primary objective was to compare the incidence of cancer in people with and without intellectual disability. Methods and Analysis A cohort study using linked population‐based administrative and cancer registry data in New South Wales, Australia 2001–
Julian Trofimovs, Claire M. Vajdic, Preeyaporn Srasuebkul, Sallie‐Anne Pearson, Julian N. Trollor   +4 more
wiley   +1 more source

Speech-language-hearing interventions in orofacial functions in individuals with Down syndrome: a scoping review. [PDF]

Codas
Correia PRB, Freire MLJ, Coêlho JF, Vasconcelos ML, Motta AR, Taveira KVM, Alves GADS.   +6 more
europepmc   +1 more source

Investigating Associations Between Psychological Distress and Changes in Peripheral Blood Monocytes in Patients With CLL/SLL Managed With Active Surveillance

Cancer Medicine, Volume 15, Issue 5, May 2026.
Among asymptomatic patients with CLL/SLL managed with active surveillance, psychological distress was associated with a lower percentage of intermediate monocytes and a greater percentage of classical monocytes. This is one of the first studies to observe that psychological distress is associated with differential patterns of monocyte distribution in ...
Carolyn Y. Fang, Alexander W. MacFarlane IV, Henry C. H. Fung, Nadia Khan, Stefan K. Barta, Jill S. Hasler, Hatcher J. Ballard, Daniel J. Landsburg, Sunita D. Nasta, Stephen J. Schuster, Rashmi Khanal, Richard I. Fisher, Adam D. Cohen, Jakub Svoboda, Kerry S. Campbell   +14 more
wiley   +1 more source

The First 13 Years of "Percorso Giacomo": Patients' Outcomes. [PDF]

Children (Basel)
Catapano F, Sperti G, Bisulli M, Corvaglia LT, Locatelli C, Parravicini E.   +5 more
europepmc   +1 more source

Racial, Ethnic, and Neighborhood Disparities in Acute Kidney Injury in Pediatric Acute Leukemia

Cancer Medicine, Volume 15, Issue 5, May 2026.
This multicenter retrospective cohort study describes racial, ethnic, and neighborhood disparities in acute kidney injury in pediatric patients with acute lymphoblastic/acute myeloid leukemia using electronic health record data. Racial and ethnic disparities were present after controlling for clinical factors.
Wendy C. Bravo, Yimei Li, Tamara P. Miller, Kelly Getz, Lusha Cao, Edward Krause, Mark Ramos, Judy Lee, Maria Monica Gramatges, Karen R. Rabin, Michael Scheurer, Richard Aplenc, Michelle Denburg   +12 more
wiley   +1 more source