Results 81 to 90 of about 11,987,893 (258)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Tritiated alumina serves as reagent for self-labeling analysis [PDF]

, 1967
Tritiated alumina, prepared by exchange of the surface hydroxyl groups with tritiated water, is a suitable reagent for exchange-labeling of specific compounds in low concentrations prior to chromatographic analysis.
Klein, P. D., Erenrich, E. H.
core  

Research Progress in Tritium Processing Technologies: A Review

Separations
Recent advancements in tritium separation technologies have significantly improved efficiency, particularly through the integration of vapor phase catalytic exchange (VPCE), liquid phase catalytic exchange (LPCE), and combined electrolysis catalytic ...
Ziqian Zhao, Yandong Sun, Qi Chen, Tianchi Li, Fang Liu, Taihong Yan, Weifang Zheng   +6 more
doaj   +1 more source

Hydrogeological studies

California Agriculture, 1962
A pilot injection of tritiated water has been made into the groundwater in a study of the groundwater and surface hydrology of foothill areas in the Sierra Nevada in Placer County.
R Burgy, D Lewis
doaj  

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

The FEBS Journal, Volume 293, Issue 11, Page 3259-3273, June 2026.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause, Marco Borsò, Marisa Müller, Axel Imhof, Zivkos Apostolou, Peter B. Becker   +5 more
wiley   +1 more source

MEASUREMENT OF D2O IN WATER USING 2H(?,n)1H REACTION [PDF]

Journal of Sciences, Islamic Republic of Iran, 2002
Utilization of Photodisintegration reaction of Deuterium, 2H(?,n)1H, is a precise technique for determining the percentage of 2H in tritiated and natural water.
doaj  

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Mapping Metal Accumulation Sites in Crop Fruits Revealed a Functional Iron Reservoir in the Tomato Seed Chalaza

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Global fruit production suffers from pre‐ and post‐harvest losses, part of which are related to metal deficiencies. Despite fruits being widely consumed plant parts, the spatial distribution of metals and their physiological significance remained largely unexplored.
Kumbirai Deon Mandebere, Utku Deniz, Katarina Vogel Mikus, Seckin Eroglu   +3 more
wiley   +1 more source

Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man1

Journal of Lipid Research, 1977
The purpose of the study was to develop a kinetic method for measurement of different parameters of cholesterol metabolism in man using labeled cholesterol precursors that could initially be incorporated even into the slowly exchangeable cholesterol pool.
M Kekki, T A Miettinen, B Wahlström
doaj   +1 more source