Results 161 to 170 of about 1,376 (263)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Strong quantum nonlocality without entanglement in every ( n - 1 ) -partition. [PDF]

iScience
Zhou H, Gao T, Yan F.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adjudication of cause of death in older adults: Learnings for death certification from the ASPirin in Reducing Events in the Elderly study. [PDF]

Clin Trials
Nelson MR, McNeil JJ, Stocks N, Panjwani S, Shah RC.   +4 more
europepmc   +1 more source

Strain driven emergence of topological non-triviality in YPdBi thin films. [PDF]

Sci Rep, 2021
Bhardwaj V, Bhattacharya A, Srivastava S, Khovaylo VV, Sannigrahi J, Banerjee N, Mani BK, Chatterjee R.   +7 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Unified and Exact Framework for Variance-Based Uncertainty Relations. [PDF]

Sci Rep, 2020
Zheng X, Ma SQ, Zhang GF, Fan H, Liu WM.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Honest yet unacceptable research practices: when research becomes a health risk. [PDF]

BMJ Open
Clark AM, Sousa BJ, Ski CF, Thompson DR.
europepmc   +1 more source

Trivial

Teresa, 2010
Hans Magnus Enzensberger, Vinicius Dantas   +1 more
openaire   +2 more sources