Results 61 to 70 of about 1,376 (263)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Extendibility, monodromy, and local triviality for topological groupoids
International Journal of Mathematics and Mathematical Sciences, 2001 A groupoid is a small category in which each morphism has an inverse. A topological groupoid is a groupoid in which both sets of objects and morphisms have topologies such that all maps of groupoid structure are continuous.
Osman Mucuk, İlhan İçen
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
MathematicsWe introduce para-associative algebroids as vector bundles whose sections form a ternary algebra with a generalised form of associativity. We show that a necessary and sufficient condition for local triviality is the existence of a differential ...
Andrew James Bruce
doaj +1 more source
On the simulation of quantum multimeters [PDF]
QuantumIn the quest for robust and universal quantum devices, the notion of simulation plays a crucial role, both from a theoretical and from an applied perspective.
Andreas Bluhm +2 more
doaj +1 more source
On Cohomological Triviality [PDF]
Proceedings of the American Mathematical Society, 1967 PROOF. As usual we proceed by induction on the order n= I GI. The theorem is trivial for n= 1. Suppose n> 1 and assume the truth of the theorem for all groups of order
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Neither a Truism nor a Triviality: Reply to Grzankowski
Principia: An International Journal of Epistemology, 2019 This is a reply to Alex Grzankowski’s comment on my paper, ‘To Believe is to Believe True’. I argue that one may believe a proposition to be true without possessing the concept of truth.
Howard Sankey
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source